2024
Functional Roles of H3K4 Methylation in Transcriptional Regulation
Yu H, Lesch B. Functional Roles of H3K4 Methylation in Transcriptional Regulation. Molecular And Cellular Biology 2024, 44: 505-515. PMID: 39155435, PMCID: PMC11529435, DOI: 10.1080/10985549.2024.2388254.Peer-Reviewed Original ResearchTranscriptional regulationAssociated with active transcriptionHistone 3 lysine 4 methylationFunctional roleTranscribed lociOpen chromatinActivate transcriptionChromatin modificationsH3K4 methylationRegulatory elementsHistone methyltransferaseEpigenetic editingTranscriptional activityResidue mutationsMammalian systemsCell differentiationHistoneH3K4me1H3K4meH3K4me3ChromatinRegulationH3K4YeastLoci
2023
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
Melnick A, Mullin C, Lin K, McCarter A, Liang S, Liu Y, Wang Q, Jerome N, Choe E, Kunnath N, Bodanapu G, Akter F, Magnuson B, Kumar S, Lombard D, Muntean A, Ljungman M, Sekiguchi J, Ryan R, Chiang M. Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress. Blood 2023, 142: 2159-2174. PMID: 37616559, PMCID: PMC10733839, DOI: 10.1182/blood.2023020144.Peer-Reviewed Original ResearchConceptsT-cell acute lymphoblastic leukemiaNotch signalingActivate transcription of genesExpression programsDNA damageTranscription of genesT-ALL oncogenesTranscription factor ETS1Elevated Notch signalingT-cell leukemia cellsImpaired mitochondrial functionGene expression profilesGene expression programsT cell developmentTranscription machineryActivate transcriptionActivate Notch signalingMitochondrial stressOncogenic NotchTargeting Notch signalingOxidative phosphorylationActivate expressionDNA repairMitochondrial functionNotch complex
1990
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
Sladek F, Zhong W, Lai E, Darnell J. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Development 1990, 4: 2353-2365. PMID: 2279702, DOI: 10.1101/gad.4.12b.2353.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBinding SitesCell NucleusCloning, MolecularDNA-Binding ProteinsGene ExpressionHepatocyte Nuclear Factor 4LiverMacromolecular SubstancesMaleMolecular Sequence DataMultigene FamilyOligonucleotide ProbesPhosphoproteinsRatsRats, Inbred StrainsReceptors, SteroidRecombinant ProteinsSequence Homology, Nucleic AcidTranscription FactorsTranscription, GeneticConceptsSteroid hormone receptor superfamilyHNF-4 proteinHNF-4Hormone receptor superfamilyReceptor SuperfamilyTranscription factor HNF-4Regulation of transcriptionAmino acid sequencePyruvate kinase geneLigand-dependent transcription factorSequence-specific fashionDNA binding activityPolymerase chain reactionHNF-4 mRNANorthern blot analysisUnusual amino acidsLF-A1CDNA clonesActivate transcriptionBinding to sitesZinc fingerCotransfection assaysDNA bindingSynthetic oligonucleotidesTranscription factors
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