Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
Melnick A, Mullin C, Lin K, McCarter A, Liang S, Liu Y, Wang Q, Jerome N, Choe E, Kunnath N, Bodanapu G, Akter F, Magnuson B, Kumar S, Lombard D, Muntean A, Ljungman M, Sekiguchi J, Ryan R, Chiang M. Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress. Blood 2023, 142: 2159-2174. PMID: 37616559, PMCID: PMC10733839, DOI: 10.1182/blood.2023020144.Peer-Reviewed Original ResearchConceptsT-cell acute lymphoblastic leukemiaNotch signalingActivate transcription of genesExpression programsDNA damageTranscription of genesT-ALL oncogenesTranscription factor ETS1Elevated Notch signalingT-cell leukemia cellsImpaired mitochondrial functionGene expression profilesGene expression programsT cell developmentTranscription machineryActivate transcriptionActivate Notch signalingMitochondrial stressOncogenic NotchTargeting Notch signalingOxidative phosphorylationActivate expressionDNA repairMitochondrial functionNotch complex
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