2019
Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition
Yadav D, Zigáčková D, Zlobina M, Klumpler T, Beaumont C, Kubíčková M, Vaňáčová Š, Lukavsky P. Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition. Nucleic Acids Research 2019, 48: 2091-2106. PMID: 31875226, PMCID: PMC7038937, DOI: 10.1093/nar/gkz1163.Peer-Reviewed Original ResearchConceptsDsRNA binding proteinSpecific mRNA targetsGroove sideMinor groove recognitionCytoplasmic mRNA levelsMRNA decayMRNA transportTranslational controlLoop anchorsMRNA targetsMinor groove sideMajor groove sideStaufen1Helix α1Sequence featuresDsRNABinding proteinGroove recognitionPhosphodiester backboneSpecific recognitionGuanine baseMRNA levelsPatterning Nanoparticles with DNA Molds
Liu L, Zheng M, Li Z, Li Q, Mao C. Patterning Nanoparticles with DNA Molds. ACS Applied Materials & Interfaces 2019, 11: 13853-13858. PMID: 30793605, DOI: 10.1021/acsami.8b22691.Peer-Reviewed Original ResearchConceptsSelf-assembled DNA nanostructuresAtomic force microscopyGold nanoparticlesNonspecific adsorptionDNA nanostructuresPatterned nanoparticlesForce microscopyNanoparticlesAccessible cavitiesSpecific recognitionStructural templateNanostructuresHexagonal arrayTemplateAdsorptionGeneral methodSubstrateDNA arraysHereinDNA templateFourier transform analysisMicroscopyArrayDirect interactionLarge array
2004
PH Domains
Lemmon M, Keleti D. PH Domains. 2004, 337-363. DOI: 10.1002/3527603611.ch17.Peer-Reviewed Original Research
1999
Chromosomal mutations induced by triplex-forming oligonucleotides in mammalian cells
Vasquez K, Wang G, Havre P, Glazer P. Chromosomal mutations induced by triplex-forming oligonucleotides in mammalian cells. Nucleic Acids Research 1999, 27: 1176-1181. PMID: 9927753, PMCID: PMC148300, DOI: 10.1093/nar/27.4.1176.Peer-Reviewed Original ResearchConceptsTriplex-forming oligonucleotidesMutation reporter geneMultiple chromosomal copiesMutation frequencyMammalian chromosomesTriplex binding siteMammalian cellsChromosomal copyFibroblast cell lineChromosomal lociGenetic manipulationMouse fibroblast cell lineSequencing dataChromosomal mutationsDuplex DNAUntreated control cellsBinding sitesCell linesControl cellsSpecific recognitionMutagenesisMutationsT transversionSpecific sitesCells
1993
Selectivity and specificity in the recognition of tRNA by E coli glutaminyl-tRNA synthetase
Rogers M, Weygand-Durašević I, Schwob E, Sherman J, Rogers K, Adachi T, Inokuchi H, Söll D. Selectivity and specificity in the recognition of tRNA by E coli glutaminyl-tRNA synthetase. Biochimie 1993, 75: 1083-1090. PMID: 8199243, DOI: 10.1016/0300-9084(93)90007-f.Peer-Reviewed Original ResearchConceptsOpal suppressor tRNAGlutaminyl-tRNA synthetaseAcceptor stem recognitionSuppressor tRNAEscherichia coli glutaminyl-tRNA synthetaseGenetic selectionAmber suppressor tRNAExtensive mutational analysisRecognition of tRNARNA contactsTRNA transcriptsRelaxed specificityMutational analysisTRNAGlnRAcceptor stemExtensive proteinIndividual functional groupsMutantsSpecific recognitionAnticodonAminoacylationSynthetaseIdentity elementSynthetases
1990
The accuracy of aminoacylation — ensuring the fidelity of the genetic code
Söll D. The accuracy of aminoacylation — ensuring the fidelity of the genetic code. Cellular And Molecular Life Sciences 1990, 46: 1089-1096. PMID: 2253707, DOI: 10.1007/bf01936918.Peer-Reviewed Original ResearchConceptsAccuracy of aminoacylationTransfer RNA speciesAminoacyl-tRNA synthetasesMessenger RNA codonRNA speciesProtein biosynthesisGenetic codeProtein interactionsParticular tRNATRNACorrect attachmentBiophysical techniquesRNA codonsAmino acidsSynthetasesSpecific recognitionProper interactionAnticodonBiosynthesisCodonAminoacylationNucleotidesSpeciesEnzymeIdentity element
1988
Site-directed mutagenesis to fine-tune enzyme specificity
Uemura H, Rogers M, Swanson R, Watson L, Söll D. Site-directed mutagenesis to fine-tune enzyme specificity. Protein Engineering Design And Selection 1988, 2: 293-296. PMID: 3150543, DOI: 10.1093/protein/2.4.293.Peer-Reviewed Original ResearchConceptsOligonucleotide-directed mutagenesisEscherichia coli glutaminyl-tRNA synthetaseGenetic selectionGlutaminyl-tRNA synthetaseAmino acid replacementsSite-directed mutagenesisAcid replacementsEnzyme specificitySingle residueMutagenesisSide chainsRepulsive charge-charge interactionsSpecific recognitionCharge-charge interactionsNucleic acidsMutantsProteinSupFSynthetaseResiduesGlutamineSelection
1979
Genetic Signals and Nucleotide Sequences in Messenger RNA
Steitz J. Genetic Signals and Nucleotide Sequences in Messenger RNA. Biological Regulation And Development 1979, 349-399. DOI: 10.1007/978-1-4684-3417-0_9.Peer-Reviewed Original ResearchRNA moleculesMessenger RNAMessenger RNA moleculesAminoacyl-tRNA synthetasesSequence of nucleotidesThree-dimensional foldingSequence of basesGenetic signalsRNA functionRibosomal RNANucleotide sequenceTRNA moleculesGenetic informationU residuesWatson-Crick base pairsTertiary structureBase pairsPolypeptide chainRNABase pairingSpecific recognitionSequenceProteinString of beadsSynthetases
1974
Specific recognition of the isolated R17 replicase initiator region by R17 coat protein
STEITZ J. Specific recognition of the isolated R17 replicase initiator region by R17 coat protein. Nature 1974, 248: 223-225. PMID: 4819415, DOI: 10.1038/248223a0.Peer-Reviewed Original Research
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