2008
Generation of human-induced pluripotent stem cells
Park IH, Lerou PH, Zhao R, Huo H, Daley GQ. Generation of human-induced pluripotent stem cells. Nature Protocols 2008, 3: 1180-1186. PMID: 18600223, DOI: 10.1038/nprot.2008.92.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsEmbryonic stem cellsIPS cellsStem cellsPatient-specific pluripotent stem cellsHuman somatic cellsInduced pluripotent stem cellsHuman iPS cellsHuman-induced pluripotent stem cellsHuman primary fibroblastsTissue replacement therapiesSomatic cellsTranscription factorsPluripotent cellsEctopic expressionRetroviral transductionSource of cellsPrimary fibroblastsHuman fibroblast lineFibroblast linesPrimary human fibroblast linesCellsInvaluable toolTransplantation of cellsImmune rejection
2000
Exploiting Nonneural Cells to Rebuild the Nervous System: From Bone Marrow to Brain
Azizi S. Exploiting Nonneural Cells to Rebuild the Nervous System: From Bone Marrow to Brain. The Neuroscientist 2000, 6: 353-361. DOI: 10.1177/107385840000600509.Peer-Reviewed Original Research
1999
Multipotential Marrow Stromal Cells Transduced to Produce L-DOPA: Engraftment in a Rat Model of Parkinson Disease
Schwarz E, Alexander G, Prockop D, Azizi S. Multipotential Marrow Stromal Cells Transduced to Produce L-DOPA: Engraftment in a Rat Model of Parkinson Disease. Human Gene Therapy 1999, 10: 2539-2549. PMID: 10543618, DOI: 10.1089/10430349950016870.Peer-Reviewed Original ResearchConceptsRat model of Parkinson's diseaseMarrow stromal cellsModel of Parkinson's diseaseRat marrow stromal cellsStromal cellsTyrosine hydroxylaseRat modelStriatum of 6-hydroxydopamine-lesioned ratsDenervated striatum of ratsL-DOPAHuman marrow stromal cellsApomorphine-induced rotationsAlternative source of cellsStriatum of ratsCells in vivoSource of cellsBone marrow stromal cellsDenervated striatumRetroviral transductionParkinson's diseaseNeural transplantationRatsConsistent with reportsIn vitroGTP cyclohydrolase IChapter 12 Fetal Grafts in Parkinson's Disease Primate Models
Sladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Chapter 12 Fetal Grafts in Parkinson's Disease Primate Models. 1999, 321-364. DOI: 10.1016/b978-012705070-6/50013-5.Peer-Reviewed Original ResearchDisease patientsFetal tissue graftsParkinson's disease patientsProgressive neurological disorderEntire striatumParkinsonian symptomsFetal graftsClinical benefitDopaminergic neuronsSubstantia nigraClinical trialsNeurosurgical interventionPrimate modelParkinson's diseaseTissue graftDonor tissueNeurological disordersSource of cellsNeurodegenerative disordersFunctional changesProgressive lossHuman embryonic tissuesOptimal ageGraftSingle donor
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