2001
Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration
Connor B, Kozlowski D, Unnerstall J, Elsworth J, Tillerson J, Schallert T, Bohn M. Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration. Experimental Neurology 2001, 169: 83-95. PMID: 11312561, DOI: 10.1006/exnr.2001.7638.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyCarrier ProteinsCocaineCorpus StriatumDisease Models, AnimalDopamineDopamine Plasma Membrane Transport ProteinsGenetic TherapyGenetic VectorsGlial Cell Line-Derived Neurotrophic FactorMaleMembrane GlycoproteinsMembrane Transport ProteinsMicroinjectionsMotor ActivityNerve Growth FactorsNerve Tissue ProteinsNeuronsNeurotransmitter AgentsOxidopamineParkinson Disease, SecondaryPresynaptic TerminalsRatsRats, Inbred F344RNA, MessengerSubstantia NigraTyrosine 3-MonooxygenaseConceptsGlial cell line-derived neurotrophic factorGDNF gene deliverySubstantia nigraDA terminalsDA neuronsNeuronal sproutingGlial cell line-derived neurotrophic factor (GDNF) gene deliveryAmphetamine-induced rotational asymmetryLine-derived neurotrophic factorUnilateral intrastriatal injectionAged rat brainDopaminergic neuronal functionTyrosine hydroxylase mRNADA transporter ligandsNigrostriatal functionStriatal injectionAxonal sproutingDopaminergic terminalsIntrastriatal injectionStriatal denervationDenervated striatumWeeks postlesionNeurotrophic factorNigrostriatal axonsPartial lesions
1999
Multipotential Marrow Stromal Cells Transduced to Produce L-DOPA: Engraftment in a Rat Model of Parkinson Disease
Schwarz E, Alexander G, Prockop D, Azizi S. Multipotential Marrow Stromal Cells Transduced to Produce L-DOPA: Engraftment in a Rat Model of Parkinson Disease. Human Gene Therapy 1999, 10: 2539-2549. PMID: 10543618, DOI: 10.1089/10430349950016870.Peer-Reviewed Original ResearchConceptsRat model of Parkinson's diseaseMarrow stromal cellsModel of Parkinson's diseaseRat marrow stromal cellsStromal cellsTyrosine hydroxylaseRat modelStriatum of 6-hydroxydopamine-lesioned ratsDenervated striatum of ratsL-DOPAHuman marrow stromal cellsApomorphine-induced rotationsAlternative source of cellsStriatum of ratsCells in vivoSource of cellsBone marrow stromal cellsDenervated striatumRetroviral transductionParkinson's diseaseNeural transplantationRatsConsistent with reportsIn vitroGTP cyclohydrolase I
1988
In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion
Hajos M, Hjorth S, Svensson K, Carlsson A. In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion. Experimental Brain Research 1988, 70: 577-584. PMID: 3133239, DOI: 10.1007/bf00247605.Peer-Reviewed Original ResearchConceptsUH 232Dopamine receptor bindingAJ 76DA lesionAutoreceptor antagonistReceptor bindingDA agonist apomorphineDA antagonist propertiesPostsynaptic DA receptorsDA receptor sensitivityDA receptorsAgonist apomorphineDenervated striatumContralateral rotationIntact striataSubstantia nigraIntact sideReceptor sensitivityAntagonist propertiesBehavioral effectsTurning behaviorAdaptational phenomenaPresent findingsLesionsAntagonist
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