2011
Inosine Augments the Effects of a Nogo Receptor Blocker and of Environmental Enrichment to Restore Skilled Forelimb Use after Stroke
Zai L, Ferrari C, Dice C, Subbaiah S, Havton LA, Coppola G, Geschwind D, Irwin N, Huebner E, Strittmatter SM, Benowitz LI. Inosine Augments the Effects of a Nogo Receptor Blocker and of Environmental Enrichment to Restore Skilled Forelimb Use after Stroke. Journal Of Neuroscience 2011, 31: 5977-5988. PMID: 21508223, PMCID: PMC3101108, DOI: 10.1523/jneurosci.4498-10.2011.Peer-Reviewed Original ResearchConceptsIntrinsic growth potentialUnilateral strokeSpinal cordLayer 5 pyramidal neuronsForelimb motor areaSimilar functional improvementEnvironmental enrichmentCause of disabilitySkilled forelimb useEffect of treatmentUndamaged cortexReceptor blockersDenervated sidePreoperative levelsNEP1-40Stroke patientsPyramidal neuronsUndamaged hemisphereSkilled reachingTreatment optionsDenervated areaIntact hemisphereReceptor antagonistClinical trialsFunctional improvement
2010
Skilled reaching training promotes astroglial changes and facilitated sensorimotor recovery after collagenase-induced intracerebral hemorrhage
Mestriner R, Pagnussat A, Boisserand L, Valentim L, Netto C. Skilled reaching training promotes astroglial changes and facilitated sensorimotor recovery after collagenase-induced intracerebral hemorrhage. Experimental Neurology 2010, 227: 53-61. PMID: 20850433, DOI: 10.1016/j.expneurol.2010.09.009.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageSensorimotor cortexNo-taskCollagenase-induced intracerebral hemorrhageRehabilitation improves recoverySpontaneous intracerebral hemorrhageAssociated with functional improvementSensorimotor recoveryIntracerebral hemorrhage groupEffective interventionsMotor trainingDorsolateral striatumForelimb sensorimotor cortexIpsilateral striatumGFAP+ cellsBehavioral testsSham groupAstrocyte densityAstrocytic changesFunctional improvementHemorrhageAstroglial changesSkilled reachingLadder walkingCellular mechanisms
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