2021
A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial
Bergenstal RM, Nimri R, Beck RW, Criego A, Laffel L, Schatz D, Battelino T, Danne T, Weinzimer SA, Sibayan J, Johnson ML, Bailey RJ, Calhoun P, Carlson A, Isganaitis E, Bello R, Albanese-O'Neill A, Dovc K, Biester T, Weyman K, Hood K, Phillip M, Group F. A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial. The Lancet 2021, 397: 208-219. PMID: 33453783, PMCID: PMC9194961, DOI: 10.1016/s0140-6736(20)32514-9.Peer-Reviewed Original ResearchConceptsAdvanced hybrid closed-loop systemType 1 diabetesHybrid closed-loop systemMiniMed 670G systemGlucose levelsCrossover trialYoung adultsMultiple daily insulin injectionsSevere hypoglycaemic eventsDaily insulin injectionsComputer-generated sequencePermuted block designContinuous glucose monitoringBaseline HbACoprimary outcomesEndocrinology practiceHypoglycaemic eventsWashout periodHemoglobin levelsKidney diseaseMean ageInsulin injectionsProportion of timeContinuous glucose monitorImpaired awareness
2018
Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management
Araque KA, Kadayakkara DK, Gigauri N, Sheehan D, Majumdar S, Buller G, Flannery CA. Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management. BMJ Open Quality 2018, 7: e000120. PMID: 29756070, PMCID: PMC5942454, DOI: 10.1136/bmjoq-2017-000120.Peer-Reviewed Original ResearchSystems-based interventionsGeneral medical wardsHypoglycaemic eventsMedian timeHospitalised adultsMedical wardsBasal-bolus insulin regimenRecurrent hypoglycaemic eventsSevere hypoglycaemic eventsFS testingHypoglycemia protocolInsulin regimenSevere hypoglycaemiaAdult patientsCumulative incidenceRecurrent hypoglycemiaSecondary outcomesAcute managementPrimary outcomeProlonged hospitalizationEndocrine consultationPhysician notificationEarly outcomesPoor outcomeMin postintervention
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