2025
Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes
Li J, Liang X, Zhao M, Luo W, Huang J, Xiao Y, Huang J, Zhao B, Zhou Z. Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes. EBioMedicine 2025, 120: 105946. PMID: 40957221, PMCID: PMC12466144, DOI: 10.1016/j.ebiom.2025.105946.Peer-Reviewed Original ResearchGenome-wide association studiesAutoimmune-mediated destructionB cellsPro-inflammatory phenotypeType 1 diabetesNOD miceT cellsIL-15T1D patientsInterleukin-15Anti-IL-15 monoclonal antibodyCD8<sup>+</sup> T cellsDisease onsetInflammatory responseAnti-CD3 monoclonal antibodyNatural Science FoundationDestruction of pancreatic B-cellsAnti-IL-15B-cell axisMonoclonal antibodiesSusceptibility to several autoimmune diseasesProduction of pro-inflammatory cytokinesIL-15 signalingSeveral autoimmune diseasesDevelopment of T1D
2023
CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
Muthana M, Du X, Liu M, Wang X, Wu W, Ai C, Su L, Zheng P, Liu Y. CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment. ELife 2023, 12 DOI: 10.7554/elife.87281.3.Peer-Reviewed Original ResearchImmune-related adverse eventsB-cell depletionB cellsT cellsSevere immune-related adverse eventsCTLA-4 antibody ipilimumabRegulatory T cell impairmentEffector memory T cellsAnti-TNF-alpha antibodyCTLA-4 deficiencyAnti-CTLA-4CD8 T cellsMemory T cellsRegulatory T cellsT cell impairmentPeripheral B cellsB cell lossReduced peripheral B cellsSeveral autoimmune diseasesKnock-In MiceAntibody-drug conjugatesAntibody ipilimumabCombination immunotherapyAutoimmune cytopeniasCTLA-4CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
Muthana M, Du X, Liu M, Wang X, Wu W, Ai C, Su L, Zheng P, Liu Y. CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment. ELife 2023, 12: rp87281. PMID: 38127423, PMCID: PMC10735222, DOI: 10.7554/elife.87281.Peer-Reviewed Original ResearchConceptsImmune-related adverse eventsB-cell depletionB cellsT cellsSevere immune-related adverse eventsCTLA-4 antibody ipilimumabRegulatory T cell impairmentEffector memory T cellsAnti-TNF-alpha antibodyAnti-CTLA-4CTLA-4 deficiencyFoxP3<sup>+</sup> TregsCD8 T cellsT cell impairmentMemory T cellsRegulatory T cellsPeripheral B cellsB cell lossReduced peripheral B cellsSeveral autoimmune diseasesKnock-In MiceAntibody-drug conjugatesAntibody ipilimumabCombination immunotherapyAutoimmune cytopenias
2022
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory
Kidani Y, Nogami W, Yasumizu Y, Kawashima A, Tanaka A, Sonoda Y, Tona Y, Nashiki K, Matsumoto R, Hagiwara M, Osaki M, Dohi K, Kanazawa T, Ueyama A, Yoshikawa M, Yoshida T, Matsumoto M, Hojo K, Shinonome S, Yoshida H, Hirata M, Haruna M, Nakamura Y, Motooka D, Okuzaki D, Sugiyama Y, Kinoshita M, Okuno T, Kato T, Hatano K, Uemura M, Imamura R, Yokoi K, Tanemura A, Shintani Y, Kimura T, Nonomura N, Wada H, Mori M, Doki Y, Ohkura N, Sakaguchi S. CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2114282119. PMID: 35140181, PMCID: PMC8851483, DOI: 10.1073/pnas.2114282119.Peer-Reviewed Original ResearchConceptsTumor TregsTumor immunityMAb treatmentTumor tissuesT cellsLong-lasting memoryCD4<sup>+</sup> regulatory T cellsPD-1 immune checkpoint blockadeCures of established tumorsInduce severe autoimmune diseaseSuppress antitumor immune responsesImmune responseT cell receptor clonotypesImmune checkpoint blockadeSystemic Treg depletionAntitumor immune responseConventional T cellsRegulatory T cellsTumor-associated antigensChemokine receptor CCR8Several autoimmune diseasesSecondary immune responseTreg depletionCheckpoint blockadePD-1
2018
Genetic variation and systemic lupus erythematosus: A field synopsis and systematic meta-analysis
Jeong D, Lee S, Park Y, Choi J, Kwon Y, Moon G, Eisenhut M, Kronbichler A, Shin J. Genetic variation and systemic lupus erythematosus: A field synopsis and systematic meta-analysis. Autoimmunity Reviews 2018, 17: 553-566. PMID: 29635078, DOI: 10.1016/j.autrev.2017.12.011.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesBayesian false discovery probabilityGenetic associations of systemic lupus erythematosusMeta-analysis of genome-wide association studiesProportion of meta-analysesMeta-analysesAssociation studiesGenetic variantsGenetic associationGenotype comparisonsObservational studyMeta-analysisP-valueSystemic lupus erythematosusDiscovery probabilityMolecular responseStatistical significancePubMed searchSeveral autoimmune diseasesInterferon signatureFalse positive resultsLoss of self-toleranceGene polymorphismsAssociation of systemic lupus erythematosusBayesian approach
2015
Familial IPEX syndrome: Different glomerulopathy in two siblings
Park E, Chang H, Shin J, Lim B, Jeong H, Lee K, Moon K, Kang H, Ha I, Cheong H. Familial IPEX syndrome: Different glomerulopathy in two siblings. Pediatrics International 2015, 57: e59-e61. PMID: 25712815, DOI: 10.1111/ped.12570.Peer-Reviewed Original ResearchConceptsMembranous nephropathyX-linked (IPEX) syndromeSeveral autoimmune diseasesImmune regulatory systemFOXP3 mutationsIPEX syndromeRenal involvementImmune dysregulationClinical featuresNephrotic syndromeAutoimmune diseasesRenal lesionsHereditary disorderTubulointerstitial diseaseGlomerular lesionsSyndromeMCNSLesionsDiseaseFoxp3PolyendocrinopathyNephropathySiblingsGlomerulopathyIPEX
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