Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes
Li J, Liang X, Zhao M, Luo W, Huang J, Xiao Y, Huang J, Zhao B, Zhou Z. Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes. EBioMedicine 2025, 120: 105946. PMID: 40957221, PMCID: PMC12466144, DOI: 10.1016/j.ebiom.2025.105946.Peer-Reviewed Original ResearchGenome-wide association studiesAutoimmune-mediated destructionB cellsPro-inflammatory phenotypeType 1 diabetesNOD miceT cellsIL-15T1D patientsInterleukin-15Anti-IL-15 monoclonal antibodyCD8<sup>+</sup> T cellsDisease onsetInflammatory responseAnti-CD3 monoclonal antibodyNatural Science FoundationDestruction of pancreatic B-cellsAnti-IL-15B-cell axisMonoclonal antibodiesSusceptibility to several autoimmune diseasesProduction of pro-inflammatory cytokinesIL-15 signalingSeveral autoimmune diseasesDevelopment of T1D
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