2012
Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions
Perrenoud Q, Rossier J, Férézou I, Geoffroy H, Gallopin T, Vitalis T, Rancillac A. Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions. Frontiers In Neural Circuits 2012, 6: 50. PMID: 22907992, PMCID: PMC3415676, DOI: 10.3389/fncir.2012.00050.Peer-Reviewed Original ResearchCerebral blood flowNeuronal nitric oxide synthase inhibitorNitric oxide synthase inhibitorNPY receptor antagonistsOxide synthase inhibitorVasoactive intestinal peptideMouse neocortical slicesBlood-vessel diameter changesVessel diameter changesNPY releaseL-NNANeurogliaform cellsRich innervationVascular toneIntestinal peptideNeuropeptide YAscending pathwaysGABAergic interneuronsReceptor antagonistSupragranular layersSerotoninergic inputSomatosensory cortexBath applicationNeocortical slicesVasoactive molecules
2011
Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats.
Kanak DJ, Jones RT, Tokhi A, Willingham AL, Zaveri HP, Rose GM, Patrylo PR. Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats. Aging And Disease 2011, 2: 318-31. PMID: 22396884, PMCID: PMC3295070.Peer-Reviewed Original ResearchNetwork excitabilityHippocampal slicesMossy fibersAdult male Fischer 344 ratsMale Fischer 344 ratsExcitotoxic glutamate analoguesCA3 networkFischer 344 ratsHigh-affinity receptorField potential activitySpread of excitabilityHilar stimulationProconvulsive effectsEpileptiform activityBath applicationAged CNSClinical dataRenal clearanceAged ratsAdult ratsAge groupsCA3 subregionExcitabilityRatsGlutamate analogue
2009
Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes
Homma R, Baker BJ, Jin L, Garaschuk O, Konnerth A, Cohen LB, Zecevic D. Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes. Philosophical Transactions Of The Royal Society B Biological Sciences 2009, 364: 2453-2467. PMID: 19651647, PMCID: PMC2865128, DOI: 10.1098/rstb.2009.0084.Peer-Reviewed Original ResearchConceptsCalcium-sensitive dyeVoltage-sensitive dyeDendrites of neuronsComplex synaptic inputsDorsal brainstemCell typesBrainstem preparationBath applicationSynaptic inputsRespiratory rhythmSpike activityTwo-photon imagingMammalian brainIon-sensitive dyesIndividual neuronsTwo-photon microscopyPopulation signalsBrainstemBrain activityIndividual cell typesNeuronsBrainMembrane potentialOutput spike trainsSpike trains
2005
Regulation of N-Methyl-D-aspartate Receptors by Calpain in Cortical Neurons*
Wu HY, Yuen EY, Lu YF, Matsushita M, Matsui H, Yan Z, Tomizawa K. Regulation of N-Methyl-D-aspartate Receptors by Calpain in Cortical Neurons*. Journal Of Biological Chemistry 2005, 280: 21588-21593. PMID: 15790561, DOI: 10.1074/jbc.m501603200.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsNMDA receptorsNMDAR currentsCortical neuronsCalpain inhibitorsCultured cortical neuronsCortical pyramidal neuronsDynamin inhibitory peptideFunction of NMDARsInhibitory peptidesInvolvement of calpainNMDAR-mediated currentsNMDAR channel functionSelective calpain inhibitorsNMDAR internalizationNMDAR overstimulationNeuroprotective mechanismsPyramidal neuronsNMDA treatmentBath applicationIntracellular injectionNR2B subunitCalcium entryPathologic functionsProlonged treatmentExcitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
Broberger C, McCormick D. Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus. Journal Of Neuroscience 2005, 25: 1664-1673. PMID: 15716402, PMCID: PMC6725920, DOI: 10.1523/jneurosci.3198-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCalcium SignalingEpilepsyFemaleFerretsGABA Antagonistsgamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsIon TransportMaleMethacholine ChlorideMuscarinic AgonistsPatch-Clamp TechniquesPotassiumPotassium ChannelsReceptors, GABA-AThalamusThyrotropin-Releasing HormoneWakefulnessConceptsThyrotropin-releasing hormoneThalamocortical cellsApplication of TRHNeuropeptide thyrotropin-releasing hormoneRapid eye movement (REM) sleepRhythmic burst firingAnti-epileptic effectsEye movement sleepApplication of bicucullineLateral geniculate nucleusSlow-wave sleepThalamocortical network activityAction potential generationSingle-spike modeNonspecific currentsPerigeniculate neuronsExcitatory effectsGABAergic neuronsMovement sleepPGN neuronsBath applicationBurst firingGeniculate nucleusIntracellular recordingsDirect depolarization
2000
Muscarinic Activation of BK Channels Induces Membrane Oscillations in Glioma Cells and Leads to Inhibition of Cell Migration
Bordey A, Sontheimer H, Trouslard J. Muscarinic Activation of BK Channels Induces Membrane Oscillations in Glioma Cells and Leads to Inhibition of Cell Migration. The Journal Of Membrane Biology 2000, 176: 31-40. PMID: 10882426, DOI: 10.1007/s00232001073.Peer-Reviewed Original ResearchConceptsPatch-clamp recordingsGlioma cellsAstrocytoma cellsCell migrationCultured human astrocytoma cellsIntracellular free calcium concentrationACh receptor agonistsFree calcium concentrationHuman astrocytoma cellsRelease of Ca2Glioma cell migrationMuscarinic activationMuscarinic antagonistCerebral tumorsMuscarinic receptorsReceptor agonistBath applicationActivate Ca2Intracellular injectionCerebrospinal fluidACh applicationAcetylcholineBiphasic increaseIntracellular storesExternal calcium
1995
The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis
Honmou O, Oyelese A, Kocsis J. The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis. Brain Research 1995, 692: 273-277. PMID: 8548315, DOI: 10.1016/0006-8993(95)00634-3.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsFree GABA levelsField potential analysisNipecotic acidGABA levelsPopulation excitatory postsynaptic potentialEffects of microapplicationRelease of GABAGABAA receptor activationAdult rat brainMechanism of actionGABA releasePartial seizuresAnticonvulsant gabapentinPresynaptic volleyPostsynaptic potentialsBath applicationHippocampal slicesRat brainGBP treatmentHippocampal cellsBlock uptakeGabapentinReceptor activationGABA
1993
Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD
Wang Z, McCormick D. Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD. Journal Of Neuroscience 1993, 13: 2199-2216. PMID: 8386756, PMCID: PMC6576582, DOI: 10.1523/jneurosci.13-05-02199.1993.Peer-Reviewed Original ResearchConceptsIntracellular recordingsMetabotropic receptorsPyramidal cellsLayer V pyramidal cellsGlutamate metabotropic receptor agonistLayer V cellsMetabotropic receptor agonistApplication of norepinephrineAlpha-agonist phenylephrineBeta-antagonist propranololSingle spike activityMuscarinic antagonist scopolamineBeta-agonist isoprenalinePrimary visual cortexAction potential generationSingle-spike modeACh effectsMuscarinic subtypesNE responseInterburst frequencyMuscarinic agonistsReceptor agonistBath applicationPostsynaptic responsesAntagonist scopolamine
1991
Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance
Shepard P, Bunney B. Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance. Experimental Brain Research 1991, 86: 141-150. PMID: 1756785, DOI: 10.1007/bf00231048.Peer-Reviewed Original ResearchConceptsAction potentialsPutative dopamine-containing neuronsEffects of apaminDopamine-containing neuronsIntracellular recording techniquesPost-spike afterhyperpolarizationRepetitive firing propertiesTypes of Ca2Apamin-sensitive Ca2Adaptive neuronal responsesZona compactaSubstantia nigraBath applicationInhibitory periodNeuronal responsesAfterhyperpolarizationApaminFiring propertiesRecording techniquesCellular mechanismsElectroresponsive propertiesFrequency adaptationSelective inhibitorInterspike intervalsNeurons
1987
Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro.
McCormick D, Prince D. Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro. The Journal Of Physiology 1987, 392: 147-165. PMID: 2833597, PMCID: PMC1192298, DOI: 10.1113/jphysiol.1987.sp016774.Peer-Reviewed Original ResearchConceptsRapid excitatory responseSlow depolarizationApplication of acetylcholineLateral geniculate nucleusGeniculate nucleusMuscarinic hyperpolarizationExcitatory responsesMuscarinic receptorsReversal potentialDorsal lateral geniculate nucleusGeniculate neuronesApparent input conductanceSingle spike activityIntracellular recording techniquesAction of acetylcholineACh-induced hyperpolarizationExtrapolated reversal potentialSingle-spike firingMechanism of actionMembrane potentialBath applicationBurst firingBurst dischargesSynaptic transmissionThalamic slices
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