2023
Previous immunity shapes immune responses to SARS-CoV-2 booster vaccination and Omicron breakthrough infection risk
Pérez-Alós L, Hansen C, Almagro Armenteros J, Madsen J, Heftdal L, Hasselbalch R, Pries-Heje M, Bayarri-Olmos R, Jarlhelt I, Hamm S, Møller D, Sørensen E, Ostrowski S, Frikke-Schmidt R, Hilsted L, Bundgaard H, Nielsen S, Iversen K, Garred P. Previous immunity shapes immune responses to SARS-CoV-2 booster vaccination and Omicron breakthrough infection risk. Nature Communications 2023, 14: 5624. PMID: 37699890, PMCID: PMC10497567, DOI: 10.1038/s41467-023-41342-2.Peer-Reviewed Original ResearchConceptsImmune responseImmune imprintingOmicron infectionIgA responsesPrimary infectionSARS-CoV-2 immune responseSARS-CoV-2 infectionT cell immune responsesBreakthrough infection riskRobust humoral responseT cell responsesBNT162b2 vaccineHybrid immunityBooster vaccinationPrevious immunityVaccinated individualsHumoral responseLow IgGViral exposurePrevious infectionSubsequent reinfectionHigh riskVaccinationOmicron variantFuture infectionsA mosquito AgTRIO mRNA vaccine contributes to immunity against malaria
Chuang Y, Alameh M, Abouneameh S, Raduwan H, Ledizet M, Weissman D, Fikrig E. A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria. Npj Vaccines 2023, 8: 88. PMID: 37286568, PMCID: PMC10244833, DOI: 10.1038/s41541-023-00679-x.Peer-Reviewed Original ResearchHumoral responseFuture malaria vaccinesMosquito saliva proteinsRobust humoral responseImmunization of miceVector antigensIsotype antibodiesIgG titersImmunized miceMalaria vaccinePassive immunizationIgG2a isotypesMRNA vaccinesPlasmodium infectionMosquito bitesMRNA lipid nanoparticlesVaccineMRNA-LNPPlasmodium sporozoitesMalariaMiceImmunizationSaliva proteinsPotential usefulnessVertebrate hosts
2010
TLR9-Targeted Biodegradable Nanoparticles as Immunization Vectors Protect against West Nile Encephalitis
Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM. TLR9-Targeted Biodegradable Nanoparticles as Immunization Vectors Protect against West Nile Encephalitis. The Journal Of Immunology 2010, 185: 2989-2997. PMID: 20660705, PMCID: PMC3753007, DOI: 10.4049/jimmunol.1000768.Peer-Reviewed Original ResearchConceptsBiodegradable nanoparticlesUnmodified nanoparticlesImmune responseNanoparticlesCell-mediated immune responsesRobust humoral responseTh1 immune responseEffector T cellsAg-specific lymphocytesTh2-biased responsesAdjuvant aluminum hydroxideWest Nile encephalitisVirus encephalitisWest Nile virusAgHumoral responseCpG oligodeoxynucleotideT cellsMouse modelLive virusInfectious agentsProtein AgVaccine developmentWN virusNile virus
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