2025
Unveiling the Mysteries of Molecular Testing in AML: A Guide for Oncologists [Podcast]
Zeidan A, Loghavi S. Unveiling the Mysteries of Molecular Testing in AML: A Guide for Oncologists [Podcast]. Blood And Lymphatic Cancer Targets And Therapy 2025, 15: 39-45. PMID: 40575712, PMCID: PMC12198350, DOI: 10.2147/blctt.s543541.Peer-Reviewed Original ResearchNext-generation sequencingAcute myeloid leukemiaSingle-gene PCRMolecular diagnosticsSingle-geneSanger sequencingGene fusionsMolecular testingRNA analysisMD Anderson Cancer CenterCapillary electrophoresisImproving clinical outcomesAML managementMyeloid leukemiaTargeted therapyClinical outcomesSequencePCRCancer CenterMolecular profilingPersonalized therapyAssay selectionClinical importanceTesting modalitiesSanger
2021
Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration
Jimenez‐Marin A, Diez I, Labayru G, Sistiaga A, Caballero M, Andres‐Benito P, Sepulcre J, Ferrer I, de Munain A, Cortes J. Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration. Neuropathology And Applied Neurobiology 2021, 47: 1092-1108. PMID: 33955002, PMCID: PMC9292638, DOI: 10.1111/nan.12725.Peer-Reviewed Original ResearchConceptsMicrotubule-associated protein tauAllen Human Brain AtlasRNA analysisSynaptic vesicle recyclingSynaptic vesicle genesHypothesis-driven genesGene clusterDopamine neurotransmitter pathwaysVesicle recyclingProtein tauTranscriptome mapTranscriptome interactionsTau pathologyMyotonic dystrophy type IBrain degenerationBiological processesGenesHuman Brain AtlasAlzheimer's diseaseTranscriptional signatureNeurobiological mechanismsCognitive functionAlpha-synucleinNeurotransmitter pathwaysRNA
2020
Analysis of transcript-deleterious variants in Mendelian disorders: implications for RNA-based diagnostics
Maddirevula S, Kuwahara H, Ewida N, Shamseldin H, Patel N, Alzahrani F, AlSheddi T, AlObeid E, Alenazi M, Alsaif H, Alqahtani M, AlAli M, Al Ali H, Helaby R, Ibrahim N, Abdulwahab F, Hashem M, Hanna N, Monies D, Derar N, Alsagheir A, Alhashem A, Alsaleem B, Alhebbi H, Wali S, Umarov R, Gao X, Alkuraya F. Analysis of transcript-deleterious variants in Mendelian disorders: implications for RNA-based diagnostics. Genome Biology 2020, 21: 145. PMID: 32552793, PMCID: PMC7298854, DOI: 10.1186/s13059-020-02053-9.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingMendelian disordersMendelian diseasesRNA-seqDiagnosis of Mendelian diseasesRNA analysisNon-coding variantsSuspected Mendelian diseasesSuspected Mendelian disordersBlood-derived RNARNA-based diagnosticsWhole-transcriptome sequencingIn silico predictionGenome sequenceRT-PCRMendelian phenotypesTranscriptome sequencingRNA sourceResults of RT-PCRModulate penetranceRNASequenceConclusionsOur resultsVariantsGenome
2018
Gaining insight into transcriptome‐wide RNA population dynamics through the chemistry of 4‐thiouridine
Duffy EE, Schofield JA, Simon MD. Gaining insight into transcriptome‐wide RNA population dynamics through the chemistry of 4‐thiouridine. Wiley Interdisciplinary Reviews - RNA 2018, 10: e1513. PMID: 30370679, PMCID: PMC6768404, DOI: 10.1002/wrna.1513.Peer-Reviewed Original ResearchConceptsDifferent RNA populationsRNA populationsNumerous experimental strategiesCellular RNA levelsMetabolic labeling experimentsRNA levelsRNA metabolismRNA turnoverRNA stabilityRNA transcriptionRNA sequencingMetabolic labelingPopulation dynamicsMetabolic labelTargeted incorporationRNA analysisRNA methodWhole cellsC mutationLabeling experimentsExperimental strategiesSequencingAvailable poolGenomeCells
2013
Extra‐transcriptional effects of RNA polymerase III transcription complex on neighboring RNA polymerase II transcribing genes in Saccharomyces cerevisiae
Korde A, Rosselot J, Donze D. Extra‐transcriptional effects of RNA polymerase III transcription complex on neighboring RNA polymerase II transcribing genes in Saccharomyces cerevisiae. The FASEB Journal 2013, 27: 980.8-980.8. DOI: 10.1096/fasebj.27.1_supplement.980.8.Peer-Reviewed Original ResearchChromatin proteinsTranscription complexRNA polymerase III transcription complexesPol III transcription complexesTransfer RNA genesPol III machineryPol III complexesPol II progressionRNA polymerase IIRNA polymerase IIINon-coding RNAsChromosome functionIntergenic transcriptionIntergenic transcriptsChromatin boundariesRNA genesInsulator functionPolymerase IIReadthrough transcriptsPolymerase IIIReduced translationRegulatory elementsS. cerevisiaeAtg31RNA analysis
1995
N-methyl-d-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons
Bading H, Segal M, Sucher N, Dudek H, Lipton S, Greenberg M. N-methyl-d-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons. Neuroscience 1995, 64: 653-664. PMID: 7715778, DOI: 10.1016/0306-4522(94)00462-e.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsBlotting, NorthernCalciumCells, CulturedElectrophysiologyGene Expression RegulationGenes, fosGenes, junGlutamic AcidGlyceraldehyde-3-Phosphate DehydrogenasesHippocampusImmunohistochemistryKainic AcidKynurenic AcidNeuronsNifedipineProto-Oncogene Proteins c-fosRatsRats, Inbred StrainsReceptors, N-Methyl-D-AspartateRNA, MessengerConceptsN-methyl-D-aspartate receptorsGene transcriptionCultured hippocampal neuronsD-aspartate receptorsRegulation of transcriptionHippocampal neuronsImmediate early gene transcriptionEarly gene transcriptionImmediate early genesTranscriptional regulationEarly gene expressionCalcium channelsTranscriptional responseCalcium imagingL-type voltage-sensitive calcium channelsN-methyl-D-aspartate (NMDA) subtypeExcitatory amino acid receptorsTranscriptional levelImmediate early gene expressionVoltage-sensitive calcium channelsNuclear runGene expressionL-type calcium channelsAmino acid receptorsRNA analysis
1991
Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum.
Lombroso P, Murdoch G, Lerner M. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 7242-7246. PMID: 1714595, PMCID: PMC52270, DOI: 10.1073/pnas.88.16.7242.Peer-Reviewed Original ResearchConceptsDeduced amino acid sequenceAmino acid consensus sequenceAmino acid sequenceApparent molecular massRat striatal cDNA librarySingle geneVitro translationCDNA clonesStrong homologyCDNA libraryCytoplasmic membraneAcid sequenceRNA transcriptsN-terminusMolecular characterizationRNA analysisMolecular massAmino acidsProteinPhosphataseMRNASequenceHomologyGenesTerminus
1980
Dimeric transfer RNA precursors in S. pombe
Mao J, Schmidt O, Söll D. Dimeric transfer RNA precursors in S. pombe. Cell 1980, 21: 509-516. PMID: 7407924, DOI: 10.1016/0092-8674(80)90488-2.Peer-Reviewed Original ResearchConceptsTRNA genesNucleotide intronRNA precursorsDNA fragmentsNuclear extractsNucleotide spacerPrimary transcription productTransfer RNA precursorsNucleotide leader sequenceS. pombeTRNA sequencesTrailer sequencesRNA initiationLeader sequenceTRNA moleculesTranscription productsEnzymatic stepsSequence analysisRNA analysisXenopus oocytesGenesEndonuclease cleavageIntronsTerminusSequence
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