2006
NMR Shifts, Orbitals, and M···H−X Bonding in d8 Square Planar Metal Complexes
Zhang Y, Lewis J, Bergman R, Ellman J, Oldfield E. NMR Shifts, Orbitals, and M···H−X Bonding in d8 Square Planar Metal Complexes. Organometallics 2006, 25: 3515-3519. DOI: 10.1021/om060163h.Peer-Reviewed Original ResearchProtein backbone hydrogen bondsSquare planar metal complexesProton NMR chemical shiftsD8 square-planar complexesNMR chemical shift changesPlanar metal complexesNMR chemical shiftsHydrogen-bonded complexesSquare-planar complexesChemical shift changesCombination of DFTMetal complexesBackbone hydrogen bondsPlanar complexesChemical shiftsPt complexesDFT calculationsAIM analysisNMR shiftsHydrogen bondsPartial covalenceElectrostatic natureMetal bondingShift changesTensor orientations
2005
Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma
Kumar A, Mandiyan V, Suzuki Y, Zhang C, Rice J, Tsai J, Artis D, Ibrahim P, Bremer R. Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma. Journal Of Molecular Biology 2005, 348: 183-193. PMID: 15808862, DOI: 10.1016/j.jmb.2005.02.039.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl ImidodiphosphateAmino Acid SequenceApoproteinsCrystallography, X-RayHumansLymphoma, Large B-Cell, DiffuseModels, MolecularMolecular Sequence DataMutationProtein BindingProtein ConformationProtein Serine-Threonine KinasesProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins c-pim-1Sequence AlignmentConceptsKinase activitySerine/threonine kinaseAberrant somatic hypermutationSomatic hypermutationKinase inhibitor scaffoldN-terminal lobePim1 mutantsTypical kinasesCo-crystal structureThreonine kinaseProtein kinaseBackbone hydrogen bondsKinase PIM1Apo formBiological functionsProline residuesPIM1 inhibitorsNovel chemical classUnique structural featuresLow molecular massInhibitor scaffoldsCell survivalMolecular massPosition 123PIM1
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