2015
Neural Regulation of Hematopoiesis, Inflammation, and Cancer
Hanoun M, Maryanovich M, Arnal-Estapé A, Frenette P. Neural Regulation of Hematopoiesis, Inflammation, and Cancer. Neuron 2015, 86: 360-373. PMID: 25905810, PMCID: PMC4416657, DOI: 10.1016/j.neuron.2015.01.026.Peer-Reviewed Original ResearchConceptsAutonomic nervous systemStem cell niche homeostasisRegulation of hematopoiesisStromal constituentsHematopoietic homeostasisHematopoietic systemTherapeutic strategiesInflammatory responseNiche homeostasisCancer cellsNeural regulationFlight-or-fight responsePeripheral innervationNervous systemCancerNeural circuitryRegulate cell behaviorInflammationHomeostasisCell behaviorHematopoiesisInnervationResponseMicroenvironment
2011
High Throughput Sequencing Following Cross-Linked Immune Precipitation (HITS-CLIP) of Argonaute (AGO) Identifies Mir-9 As a Regulator of MMP2 in the Marrow Microenvironment (ME)
Balakrishnan I, Yang X, Torok-Storb B, Hesselberth J, Pillai M. High Throughput Sequencing Following Cross-Linked Immune Precipitation (HITS-CLIP) of Argonaute (AGO) Identifies Mir-9 As a Regulator of MMP2 in the Marrow Microenvironment (ME). Blood 2011, 118: 2392. DOI: 10.1182/blood.v118.21.2392.2392.Peer-Reviewed Original ResearchGenome-wide approachesHITS-CLIPMiRNA-mRNA interactomeMiR-9Functional nichesNext-generation sequencingHuman umbilical vein endothelial cellsGene expressionMarrow microenvironmentNew genome-wide approachDirect bindingLuciferase assayMiRNA-based regulationPost-transcriptional regulationCross-species conservationSpecific functional nichesHigh-throughput sequencingMiRNA-mRNA interactionsSmall noncoding RNAsRegulation of hematopoiesisPutative binding sitesStromal cellsCobblestone areaSequence-specific fashionCross-linked RNA
2009
Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells.
Raaijmakers M, Mukherjee S, Guo S, Kobayashi T, Schoonmaker J, Aung Z, Ebert B, Al-Shahrour F, Hasserjian R, Vallet S, Scadden E, Lin C, Scadden D. Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells. Blood 2009, 114: 247. DOI: 10.1182/blood.v114.22.247.247.Peer-Reviewed Original ResearchDeletion of Dicer1Hematopoietic cellsMyelodysplastic syndromeHuman myelodysplastic syndromeOsteoprogenitor cellsHematopoietic abnormalitiesHematopoietic systemMesenchymal cellsWild-type environmentRegulation of hematopoiesisGene expression profilingWild-type hematopoietic cellsB cell progenitorsPrimitive hematopoietic cellsHematopoietic physiologyMiRNA biogenesisOrgan formationTranscriptional controlOsteolineage cellsNormal stem cellsGermline tissuesComparative genomic hybridizationMultiple lineagesExpression profilingBone marrow vascularity
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