2015
The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice
Bausch AE, Dieter R, Nann Y, Hausmann M, Meyerdierks N, Kaczmarek LK, Ruth P, Lukowski R. The sodium-activated potassium channel Slack is required for optimal cognitive flexibility in mice. Learning & Memory 2015, 22: 323-335. PMID: 26077685, PMCID: PMC4478330, DOI: 10.1101/lm.037820.114.Peer-Reviewed Original ResearchConceptsFragile X Mental Retardation ProteinCognitive flexibilityFragile X syndromeNormal working memoryAspects of memoryIntellectual disabilityMental retardation proteinSpatial learning capabilitiesSlack channelsWorking memoryBehavioral tasksReference memorySodium-activated potassium channel SlackHigher brain functionsUnfamiliar situationsBrain functionSevere intellectual disabilityMemoryIntellectual developmentSodium-activated potassium channelsNull mouse modelGeneral locomotor activityX syndromeProper functionLearning capabilities
2014
Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability
Truong D, Che A, Rendall A, Szalkowski C, LoTurco J, Galaburda A, Fitch R. Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability. Genes Brain & Behavior 2014, 13: 802-811. PMID: 25130614, PMCID: PMC4241168, DOI: 10.1111/gbb.12170.Peer-Reviewed Original ResearchConceptsRapid auditory processingPhonological processingWorking memoryMemory abilityAssociated with specific difficultiesAuditory processingShort-term/working memoryRadial arm mazeAssociated with dyslexiaImpaired reading abilityComplex neurodevelopmental disorderArm mazeReference memoryInhibition paradigmBehavioral tasksBehavioral impairmentsBehavioral resultsReading abilityDCDC2 mutationsNeurodevelopmental disordersVisual attentionSpecific difficultiesDCDC2 geneGenetic variantsNormal intellect
2012
Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM. Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus. Biological Psychiatry 2012, 71: 1090-1098. PMID: 22541947, PMCID: PMC3371339, DOI: 10.1016/j.biopsych.2012.03.013.Peer-Reviewed Original ResearchConceptsFGF receptor 2Fibroblast growth factorDentate gyrusReceptor 2Embryonic knockoutWater maze probe trialGrowth factor receptor 2Reference memoryFactor receptor 2Spatial reference memoryNeural stem cellsFibroblast growth factor receptor 2Immature neuronsCortical neuronsHippocampal volumeInducible knockout miceParvalbumin interneuronsShort-term learningGranule cellsKnockout miceSeparate cellular componentsHippocampusLong-term reference memoryAdult spatial memoryGrowth factor
2007
Select Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working Memory
Celikel T, Marx V, Freudenberg F, Zivkovic A, Resnik E, Hasan MT, Licznerski P, Osten P, Rozov A, Seeburg PH, Schwarz MK. Select Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working Memory. Frontiers In Neuroscience 2007, 1: 97-110. PMID: 18982121, PMCID: PMC2518050, DOI: 10.3389/neuro.01.1.1.007.2007.Peer-Reviewed Original ResearchLong-term potentiationSynaptic plasticityCA3-CA1 long-term potentiationLong Homer isoformsPostsynaptic excitatory neuronsSpatial working memoryOverexpression of Homer1aDorsal hippocampusGlutamate receptorsExcitatory neuronsSynaptic transmissionCortical areasImpairs spatial working memoryHomer isoformsSimilar impairmentHomer1aLong HomersSpatial workingReference memorySpatial memoryHippocampusFunctional competitionImpairmentOverexpressionExpression of Venus
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