A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking
Wang S, Kim S, Cosgrove KP, Morris ED. A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking. NeuroImage 2016, 146: 701-714. PMID: 27743899, PMCID: PMC5321849, DOI: 10.1016/j.neuroimage.2016.10.019.Peer-Reviewed Original ResearchConceptsNeurotransmitter responsesCigarette smokingDrug stimuliDA releaseDA activationBolus injectionMild shorteningPET scansOptimal timingSmokingDopamine responsePET dataLp-ntPETDose limitTime courseSex differencesScansLoss of sensitivityBehavioral tasksDrugsLinear parametric neurotransmitter PETLower dose limitSuch responsesResponseStimuli