2024
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Mevenkamp J, Bruls Y, Mancilla R, Grevendonk L, Wildberger J, Brouwers K, Hesselink M, Schrauwen P, Hoeks J, Houtkooper R, Buitinga M, de Graaf R, Lindeboom L, Schrauwen-Hinderling V. Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T. Nature Communications 2024, 15: 9159. PMID: 39443469, PMCID: PMC11499639, DOI: 10.1038/s41467-024-53292-4.Peer-Reviewed Original ResearchConceptsPhysically active older adultsActive older adultsMetabolic healthHuman skeletal musclePhosphorous magnetic resonance spectroscopySedentary individualsOlder adultsStimulate mitochondrial biogenesisHealthSkeletal muscleMitochondrial biogenesisNAD+Physiological decreaseNADH contentNADHQuantify NADHClinical 3Magnetic resonance spectroscopy techniquesMR sequencesAdultsMeasurement reproducibility
2017
Measurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing
Lindeboom L, de Graaf R. Measurement of lipid composition in human skeletal muscle and adipose tissue with 1H‐MRS homonuclear spectral editing. Magnetic Resonance In Medicine 2017, 79: 619-627. PMID: 28474367, DOI: 10.1002/mrm.26740.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAlgorithmsHumansLipidsMaleMiddle AgedMuscle, SkeletalPhantoms, ImagingProton Magnetic Resonance SpectroscopyConceptsAdipose tissueProton magnetic resonance spectroscopySkeletal muscleH-MRSAccumulation of triglyceridesInvasive biopsyMetabolic derangementsEctopic fatInsulin resistanceCardiovascular diseaseMetabolic diseasesMEGA-sLASER sequenceIn vivoNonadipose tissuesLipid resonancesSpectral editingPolyunsaturated fatty acidsHuman skeletal muscleMagnetic resonance spectroscopyLipid storesLipid compositionAdiposeSpectral resolutionTissuePhantom experiments
2001
Diffusion NMR spectroscopy
Nicolay K, Braun K, de Graaf R, Dijkhuizen R, Kruiskamp M. Diffusion NMR spectroscopy. NMR In Biomedicine 2001, 14: 94-111. PMID: 11320536, DOI: 10.1002/nbm.686.Peer-Reviewed Original Research
2000
In Vivo 31P-NMR Diffusion Spectroscopy of ATP and Phosphocreatine in Rat Skeletal Muscle
de Graaf R, van Kranenburg A, Nicolay K. In Vivo 31P-NMR Diffusion Spectroscopy of ATP and Phosphocreatine in Rat Skeletal Muscle. Biophysical Journal 2000, 78: 1657-1664. PMID: 10733948, PMCID: PMC1300762, DOI: 10.1016/s0006-3495(00)76717-8.Peer-Reviewed Original Research
1999
Magnetic coupling of creatine/phosphocreatine protons in rat skeletal muscle, as studied by 1H‐magnetization transfer MRS
Kruiskamp M, de Graaf R, van Vliet G, Nicolay K. Magnetic coupling of creatine/phosphocreatine protons in rat skeletal muscle, as studied by 1H‐magnetization transfer MRS. Magnetic Resonance In Medicine 1999, 42: 665-672. PMID: 10502754, DOI: 10.1002/(sici)1522-2594(199910)42:4<665::aid-mrm7>3.0.co;2-9.Peer-Reviewed Original Research