2012
Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal study
Booij L, Benkelfat C, Leyton M, Vitaro F, Gravel P, Lévesque M, Arseneault L, Diksic M, Tremblay R. Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal study. European Neuropsychopharmacology 2012, 22: 419-423. PMID: 22257439, DOI: 10.1016/j.euroneuro.2011.11.002.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexOrbitofrontal cortexSerotonin neurotransmissionPerinatal adversityPositron emission tomography scanEarly postnatal stressorsLow birth weightEmission tomography scanBrain serotonin neurotransmissionBrain serotonin synthesisSerotonin synthesis capacityStudies reporting associationLongitudinal studyMental health problemsEffects of childhoodLife-long impactTracer alphaMaternal smokingPerinatal effectsBirth complicationsBirth weightRisk factorsTomography scanSerotonin pathwaySerotonin synthesis
2010
Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study
Booij L, Tremblay R, Leyton M, Séguin J, Vitaro F, Gravel P, Perreau-Linck E, Lévesque M, Durand F, Diksic M, Turecki G, Benkelfat C. Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study. PLOS ONE 2010, 5: e11255. PMID: 20582306, PMCID: PMC2889822, DOI: 10.1371/journal.pone.0011255.Peer-Reviewed Original ResearchMeSH KeywordsAdultAggressionBrainEmotionsHumansLongitudinal StudiesMaleMemoryPositron-Emission TomographySerotoninTryptophanConceptsPhysical aggressionLongitudinal studyHigher physical aggressionLow serotonin neurotransmissionImpulsive aggressive behaviorSubstance abuse disordersEmotional intelligenceComputerized measuresVulnerability traitsVulnerability factorsOrbitofrontal cortexEnvironmental supportGroup differencesAggressionAbuse disordersAggressive behaviorTracer alphaMultiple indicesPlasma tryptophan levelsBrain serotonin synthesisLow trappingPositron emission tomographyCurrent behaviorSerotonin neurotransmissionImpulsivity