2016
Cocaine cue–induced dopamine release in the human prefrontal cortex
Milella M, Fotros A, Gravel P, Casey K, Larcher K, Verhaeghe J, Cox S, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine cue–induced dopamine release in the human prefrontal cortex. Journal Of Psychiatry And Neuroscience 2016, 41: 322-330. PMID: 26900792, PMCID: PMC5008921, DOI: 10.1503/jpn.150207.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzamidesBrain MappingCocaineCocaine-Related DisordersCorpus StriatumCravingCuesDopamineDopamine D2 Receptor AntagonistsDopamine Uptake InhibitorsFemaleFluorine RadioisotopesHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPositron-Emission TomographyPrefrontal CortexRadiopharmaceuticalsConceptsDA releaseMedial orbitofrontal cortexPrefrontal cortexDrug-related cuesDopamine releaseHuman prefrontal cortexOrbitofrontal cortexCortical DA releasePresence of autoreceptorsDA cell bodiesD2 receptor levelsD2/3 receptor availabilityCurrent cocaine dependencePositron emission tomographyCocaine use disorderDorsolateral prefrontal cortexSelf-reported cravingStriatal changesHigh-resolution positron emission tomographyReceptor levelsSeparate regulatory mechanismsStriatal regionsDA responseUse disordersReceptor availability
2013
Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants
Fotros A, Casey K, Larcher K, Verhaeghe J, Cox S, Gravel P, Reader A, Dagher A, Benkelfat C, Leyton M. Cocaine Cue-Induced Dopamine Release in Amygdala and Hippocampus: A High-Resolution PET [18F]Fallypride Study in Cocaine Dependent Participants. Neuropsychopharmacology 2013, 38: 1780-1788. PMID: 23546387, PMCID: PMC3717549, DOI: 10.1038/npp.2013.77.Peer-Reviewed Original ResearchConceptsDA releaseDopamine releaseVisual analog scaleDrug cue exposureCocaine-dependent volunteersDrug-seeking behaviorCocaine-dependent participantsAnalog scaleDrug-related cuesLimbic networkAnimal studiesCocaine dependenceHippocampusCue exposureAmygdalaPreferential inductionBPND valuesPotent triggerStriatumDependent participantsCocaine cuesReward networkSubjective responsesNeutral cuesFirst evidence
2006
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder
Mazza S, Soucy J, Gravel P, Michaud M, Postuma R, Massicotte-Marquez J, Decary A, Montplaisir J. Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. Neurology 2006, 67: 1618-1622. PMID: 17101893, DOI: 10.1212/01.wnl.0000242879.39415.49.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrainBrain StemCerebral ArteriesCerebral CortexCerebrovascular CirculationCorpus StriatumCysteineFemaleHumansMaleMiddle AgedNeurodegenerative DiseasesOrganotechnetium CompoundsParkinson DiseasePolysomnographyPredictive Value of TestsPrognosisREM Sleep Behavior DisorderTomography, Emission-Computed, Single-PhotonConceptsREM behavior disorderBehavior disorderCerebral blood flow evaluationREM sleep behavior disorderIdiopathic REM behavior disorderSleep behavior disorderBrain perfusion changesRegional cerebral perfusionBlood flow evaluationAge-matched controlsTemporo-parietal cortexCerebral perfusionDecreased perfusionPerfusion changesPerfusional abnormalitiesRight hippocampusParkinson's diseasePatientsMetabolic profilePerfusionDisordersAbnormalitiesCortexFlow evaluationBrainstem