2010
Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study
Booij L, Tremblay R, Leyton M, Séguin J, Vitaro F, Gravel P, Perreau-Linck E, Lévesque M, Durand F, Diksic M, Turecki G, Benkelfat C. Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study. PLOS ONE 2010, 5: e11255. PMID: 20582306, PMCID: PMC2889822, DOI: 10.1371/journal.pone.0011255.Peer-Reviewed Original ResearchConceptsPhysical aggressionLongitudinal studyHigher physical aggressionLow serotonin neurotransmissionImpulsive aggressive behaviorSubstance abuse disordersEmotional intelligenceComputerized measuresVulnerability traitsVulnerability factorsOrbitofrontal cortexEnvironmental supportGroup differencesAggressionAbuse disordersAggressive behaviorTracer alphaMultiple indicesPlasma tryptophan levelsBrain serotonin synthesisLow trappingPositron emission tomographyCurrent behaviorSerotonin neurotransmissionImpulsivity
2005
α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters
Leyton M, Paquette V, Gravel P, Rosa-Neto P, Weston F, Diksic M, Benkelfat C. α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology 2005, 16: 220-223. PMID: 16269239, DOI: 10.1016/j.euroneuro.2005.09.006.Peer-Reviewed Original ResearchConceptsL-tryptophan trappingPrefrontal cortexHealthy controlsSerotonin synthesisSuicidal behaviorSuicide attemptersRegional serotonin synthesisHigh-lethality suicide attemptsVentral medial prefrontal cortexLow serotonin neurotransmissionMedial prefrontal cortexSerotonin neurotransmissionVentromedial prefrontal cortexSuicide attemptsSuicide intentCortexAlphaAttemptersPatientsNeurotransmission