2012
GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation
Qin P, Duncan N, Wiebking C, Gravel P, Lyttelton O, Hayes D, Verhaeghe J, Kostikov A, Schirrmacher R, Reader A, Northoff G. GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation. Frontiers In Human Neuroscience 2012, 6: 337. PMID: 23293594, PMCID: PMC3533380, DOI: 10.3389/fnhum.2012.00337.Peer-Reviewed Original ResearchAuditory cortexFunctional connectivityVisual cortexInter-regional functional connectivityNeural activityNeural activity changesBrain activityLocal brain activityStimulus-induced activityVisual stimuliRecent imaging studiesEyes-open stateHaemodynamic responseGABA systemΓ-aminobutyric acidGABAA receptorsReceptor levelsGABA concentrationImaging studiesCortexVisual stimulationReceptorsSimple visual stimuliDiscrete visual stimulusClosed eyes
2011
Tryptophan hydroxylase2 gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans
Booij L, Turecki G, Leyton M, Gravel P, Lopez De Lara C, Diksic M, Benkelfat C. Tryptophan hydroxylase2 gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans. Molecular Psychiatry 2011, 17: 809-817. PMID: 21747395, DOI: 10.1038/mp.2011.79.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin synthesisTryptophan hydroxylase 2Orbitofrontal cortexRate-limiting enzymeSingle nucleotide polymorphismsL-tryptophan trappingRegional serotonin synthesisBrain serotonin synthesisTPH2 single nucleotide polymorphismsDose-effect relationshipBrain clearanceHealthy controlsGene polymorphismsAggressive behavioral phenotypeEmission tomographyHydroxylase 2TPH2 geneGenetic factorsCortexBehavioral phenotypesPolymorphismPatientsHumansLarge sample
2006
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder
Mazza S, Soucy J, Gravel P, Michaud M, Postuma R, Massicotte-Marquez J, Decary A, Montplaisir J. Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. Neurology 2006, 67: 1618-1622. PMID: 17101893, DOI: 10.1212/01.wnl.0000242879.39415.49.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrainBrain StemCerebral ArteriesCerebral CortexCerebrovascular CirculationCorpus StriatumCysteineFemaleHumansMaleMiddle AgedNeurodegenerative DiseasesOrganotechnetium CompoundsParkinson DiseasePolysomnographyPredictive Value of TestsPrognosisREM Sleep Behavior DisorderTomography, Emission-Computed, Single-PhotonConceptsREM behavior disorderBehavior disorderCerebral blood flow evaluationREM sleep behavior disorderIdiopathic REM behavior disorderSleep behavior disorderBrain perfusion changesRegional cerebral perfusionBlood flow evaluationAge-matched controlsTemporo-parietal cortexCerebral perfusionDecreased perfusionPerfusion changesPerfusional abnormalitiesRight hippocampusParkinson's diseasePatientsMetabolic profilePerfusionDisordersAbnormalitiesCortexFlow evaluationBrainstem
2005
α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters
Leyton M, Paquette V, Gravel P, Rosa-Neto P, Weston F, Diksic M, Benkelfat C. α-[11C]Methyl-l-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology 2005, 16: 220-223. PMID: 16269239, DOI: 10.1016/j.euroneuro.2005.09.006.Peer-Reviewed Original ResearchConceptsL-tryptophan trappingPrefrontal cortexHealthy controlsSerotonin synthesisSuicidal behaviorSuicide attemptersRegional serotonin synthesisHigh-lethality suicide attemptsVentral medial prefrontal cortexLow serotonin neurotransmissionMedial prefrontal cortexSerotonin neurotransmissionVentromedial prefrontal cortexSuicide attemptsSuicide intentCortexAlphaAttemptersPatientsNeurotransmission