2015
Low-spatial-coherence high-radiance broadband fiber source for speckle free imaging.
Redding B, Ahmadi P, Mokan V, Seifert M, Choma MA, Cao H. Low-spatial-coherence high-radiance broadband fiber source for speckle free imaging. Optics Letters 2015, 40: 4607-10. PMID: 26469575, DOI: 10.1364/ol.40.004607.Peer-Reviewed Original ResearchConceptsFiber ASE sourceFull-field imagingLow temporal coherenceASE sourceHigh powerSpeckle-free imagingContinuous wave emissionLow spatial coherenceSpontaneous emission sourceHalf-maximum bandwidthCore multimode fiberTemporal coherenceOptical feedbackWave emissionMultimode fiberSpatial modesFull widthFree imagingSpatial coherenceSpectral compoundingSpeckle suppressionEmission sourcesCoherenceEmissionFiber sourceQuantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography
Gamm UA, Huang BK, Syed M, Zhang X, Bhandari V, Choma MA. Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography. Journal Of Biomedical Optics 2015, 20: 080505-080505. PMID: 26308164, PMCID: PMC4874052, DOI: 10.1117/1.jbo.20.8.080505.Peer-Reviewed Original ResearchConceptsOptical coherence tomographyMouse tracheaCoherence tomographyDrug-mediated modulationIntensive care unitRisk-benefit profileRespiratory failureCare unitOxygen supplementationRespiratory mucosaRespiratory epitheliumIndispensable treatmentImpaired capacityClinical useHyperoxiaTracheaFlow quantificationTomographyTreatmentDamagePatientsMucosaSupplementationEpitheliumThree-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography
Huang BK, Gamm UA, Bhandari V, Khokha MK, Choma MA. Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography. Biomedical Optics Express 2015, 6: 3515-3538. PMID: 26417520, PMCID: PMC4574676, DOI: 10.1364/boe.6.003515.Peer-Reviewed Original ResearchDigital particle image velocimetryFluid flowVelocimetry measurementsParticle image velocimetryImage velocimetryFlow performanceFlow velocity measurementsVelocimetryVelocity measurementsLow-dimensional measurementsDimensional measurementsS regimeFlowNoise ratioCilia-driven fluid flowMeasurementsFlow imagingCorrelation-based approachSmartphone-based diagnostic for preeclampsia: an mHealth solution for administering the Congo Red Dot (CRD) test in settings with limited resources
Jonas SM, Deserno TM, Buhimschi CS, Makin J, Choma MA, Buhimschi IA. Smartphone-based diagnostic for preeclampsia: an mHealth solution for administering the Congo Red Dot (CRD) test in settings with limited resources. Journal Of The American Medical Informatics Association 2015, 23: 166-173. PMID: 26026158, PMCID: PMC7814923, DOI: 10.1093/jamia/ocv015.Peer-Reviewed Original ResearchQuantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology
Huang BK, Gamm UA, Jonas S, Khokha MK, Choma MA. Quantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology. Journal Of Biomedical Optics 2015, 20: 030502-030502. PMID: 25751026, PMCID: PMC4352652, DOI: 10.1117/1.jbo.20.3.030502.Peer-Reviewed Original ResearchLow spatial coherence electrically pumped semiconductor laser for speckle-free full-field imaging
Redding B, Cerjan A, Huang X, Lee ML, Stone AD, Choma MA, Cao H. Low spatial coherence electrically pumped semiconductor laser for speckle-free full-field imaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1304-1309. PMID: 25605946, PMCID: PMC4321308, DOI: 10.1073/pnas.1419672112.Peer-Reviewed Original ResearchConceptsLow spatial coherenceFull-field imagingLight-emitting diodesSpatial coherenceSemiconductor lasersLaser sourceLight sourceConventional laser sourcesThermal light sourceIncoherent light sourceHigh spectral radianceIndependent spatial modesCavity laserLaser resonatorCoherent artifactsSample illuminationSpatial modesProjection applicationsIllumination sourceLaserEmitting diodesOrders of magnitudeSpectral radianceThermal sourceHigh power
2014
Microscale imaging of cilia-driven fluid flow
Huang BK, Choma MA. Microscale imaging of cilia-driven fluid flow. Cellular And Molecular Life Sciences 2014, 72: 1095-1113. PMID: 25417211, PMCID: PMC4605231, DOI: 10.1007/s00018-014-1784-z.Peer-Reviewed Original ResearchResolving directional ambiguity in dynamic light scattering-based transverse motion velocimetry in optical coherence tomography.
Huang BK, Choma MA. Resolving directional ambiguity in dynamic light scattering-based transverse motion velocimetry in optical coherence tomography. Optics Letters 2014, 39: 521-4. PMID: 24487855, PMCID: PMC4174353, DOI: 10.1364/ol.39.000521.Peer-Reviewed Original ResearchConceptsTotal transverseDirectional velocityFunction calibrationTomography approachDirectional ambiguityScan axisDirectional velocity componentsThree-component velocimetryOptical coherence tomographyTransverse planeVelocity componentsLongitudinal angleCoherence tomographyDoppler velocimetryVelocimetryTransversePlane
2013
A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface
Jonas S, Zhou E, Deniz E, Huang B, Chandrasekera K, Bhattacharya D, Wu Y, Fan R, Deserno TM, Khokha MK, Choma MA. A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface. Lab On A Chip 2013, 13: 4160-4163. PMID: 23970350, PMCID: PMC3856250, DOI: 10.1039/c3lc50571e.Peer-Reviewed Original Research
2012
Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography.
Deniz E, Jonas S, Khokha M, Choma MA. Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography. Optics Letters 2012, 37: 2979-81. PMID: 22825198, PMCID: PMC3881542, DOI: 10.1364/ol.37.002979.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseBiomechanical phenotypingSmall animal modelsMicroangiography techniqueCardiac dysfunctionEmbryonic heartHeart diseaseCardiac performanceEndogenous hemoglobin contrastContrast angiographyBlood flowCardioactive drugsAnimal modelsSubtraction angiographyVivo assessmentFunctional optical imagingHemoglobin contrastMalformed heartsAngiographyFlow imagingHeartPhysiological responsesImagingDysfunctionPhenotypingSpeckle-free laser imaging using random laser illumination
Redding B, Choma MA, Cao H. Speckle-free laser imaging using random laser illumination. Nature Photonics 2012, 6: 355-359. PMID: 24570762, PMCID: PMC3932313, DOI: 10.1038/nphoton.2012.90.Peer-Reviewed Original ResearchRandom lasersSuperluminescent diodeCoherent artifactsLaser illuminationImaging applicationsSpatial coherenceThermal light sourceIntense laser illuminationHigh spatial coherenceLow spatial coherenceBright light-emitting diodesLight-emitting diodesOptical scatteringCoherent illuminationLight sourceLaserIllumination sourceLaser imagingDiodesIlluminationCoherenceScatteringBrightnessSpeckleSource
2011
Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry
Jonas S, Bhattacharya D, Khokha MK, Choma MA. Microfluidic characterization of cilia-driven fluid flow using optical coherence tomography-based particle tracking velocimetry. Biomedical Optics Express 2011, 2: 2022-2034. PMID: 21750777, PMCID: PMC3130586, DOI: 10.1364/boe.2.002022.Peer-Reviewed Original Research
2010
Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems
Choma MA, Suter MJ, Vakoc BJ, Bouma BE, Tearney GJ. Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems. Disease Models & Mechanisms 2010, 4: 411-420. PMID: 21183476, PMCID: PMC3097462, DOI: 10.1242/dmm.005231.Peer-Reviewed Original Research
2005
Spectral-domain phase microscopy.
Choma MA, Ellerbee AK, Yang C, Creazzo TL, Izatt JA. Spectral-domain phase microscopy. Optics Letters 2005, 30: 1162-4. PMID: 15945141, DOI: 10.1364/ol.30.001162.Peer-Reviewed Original ResearchConceptsSpectral domain phase microscopyShot-noise limitPhase-sensitive techniqueNanometer-scale motionCoherence gatingBroadband interferometryDisplacement sensitivityPhase microscopyPhase informationOptical coherence tomographyCoherence tomographyFunctional extensionAttractive techniqueInterferometryLiving cellsCellular motionMotionCellular dynamicsMicroscopyMeasurementsTechniqueGating
2003
Sensitivity advantage of swept source and Fourier domain optical coherence tomography
Choma M, Sarunic M, Yang C, Izatt J. Sensitivity advantage of swept source and Fourier domain optical coherence tomography. Optics Express 2003, 11: 2183-9. PMID: 19466106, DOI: 10.1364/oe.11.002183.Peer-Reviewed Original Research