Michael Choma, MD, PhD
Associate Professor AdjunctCards
Appointments
Contact Info
Radiology & Biomedical Imaging
TAC N117, PO BOX 208043
New Haven, CT 06520-8043
United States
About
Titles
Associate Professor Adjunct
Biography
Dr. Choma is a physician-engineer with expertise in digital health, AI/computer vision, medical imaging, medical physiology, and biomedical optics. He is an Adjunct Associate Professor at Yale, where he teaches Data and Clinical Decision-Making (ENAS 523). His writings on the ongoing evolution of medicine in the era of data and computation can be found on Substack. He occasionally posts on LinkedIn and Threads.
Dr. Choma also was the VP Clinical at LookDeep Health, a Bay-Area startup that develops AI/computer vision technologies for inpatient telemedicine and patient monitoring. He leads their clinical science efforts, with an emphasis on leveraging several academic-industrial partnerships that focus on high-value clinical use-cases (e.g. preventing avoidable harm).
Previously, Dr. Choma was full-time faculty at Yale as an Associate Professor. He ran an NIH-funded biophotonics laboratory that developed optical coherence tomography (OCT) technologies to study pulmonary and cardiovascular physiology. In addition, he was an attending physician in the Yale-New Haven Primary Care Clinic. His prior experience also includes working on the brain-computer interface project at Meta (previously Facebook).
Dr. Choma received his MD and PhD degrees from Duke University. He trained in general pediatrics at Boston Children’s Hospital, and his postdoc was at the Wellman Center for Photomedicine at Massachusetts General Hospital / Harvard Medical School.
Appointments
Radiology & Biomedical Imaging
Associate Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- MD
- Duke University (2006)
- PhD
- Duke University (2004)
- Intern
- Children's Hospital Boston
- Resident
- Children's Hospital Boston
- Resident
- Yale-New Haven Hospital
Research
Overview
- Optical imaging of microfluidic-scale biological fluid flow
- Quantitative imaging of embryo heart physiology and pathophysiology
- Diagnostic imaging of pathologic cilia-driven fluid flow
- Developing novel light sources for biological imaging
Medical Research Interests
Public Health Interests
Research at a Glance
Publications Timeline
Research Interests
Tomography, Optical Coherence
Cilia
Lasers
Publications
2015
Low-spatial-coherence high-radiance broadband fiber source for speckle free imaging.
Redding B, Ahmadi P, Mokan V, Seifert M, Choma MA, Cao H. Low-spatial-coherence high-radiance broadband fiber source for speckle free imaging. Optics Letters 2015, 40: 4607-10. PMID: 26469575, DOI: 10.1364/ol.40.004607.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFiber ASE sourceFull-field imagingLow temporal coherenceASE sourceHigh powerSpeckle-free imagingContinuous wave emissionLow spatial coherenceSpontaneous emission sourceHalf-maximum bandwidthCore multimode fiberTemporal coherenceOptical feedbackWave emissionMultimode fiberSpatial modesFull widthFree imagingSpatial coherenceSpectral compoundingSpeckle suppressionEmission sourcesCoherenceEmissionFiber sourceQuantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography
Gamm UA, Huang BK, Syed M, Zhang X, Bhandari V, Choma MA. Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography. Journal Of Biomedical Optics 2015, 20: 080505-080505. PMID: 26308164, PMCID: PMC4874052, DOI: 10.1117/1.jbo.20.8.080505.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOptical coherence tomographyMouse tracheaCoherence tomographyDrug-mediated modulationIntensive care unitRisk-benefit profileRespiratory failureCare unitOxygen supplementationRespiratory mucosaRespiratory epitheliumIndispensable treatmentImpaired capacityClinical useHyperoxiaTracheaFlow quantificationTomographyTreatmentDamagePatientsMucosaSupplementationEpitheliumThree-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography
Huang BK, Gamm UA, Bhandari V, Khokha MK, Choma MA. Three-dimensional, three-vector-component velocimetry of cilia-driven fluid flow using correlation-based approaches in optical coherence tomography. Biomedical Optics Express 2015, 6: 3515-3538. PMID: 26417520, PMCID: PMC4574676, DOI: 10.1364/boe.6.003515.Peer-Reviewed Original ResearchCitationsConceptsDigital particle image velocimetryFluid flowVelocimetry measurementsParticle image velocimetryImage velocimetryFlow performanceFlow velocity measurementsVelocimetryVelocity measurementsLow-dimensional measurementsDimensional measurementsS regimeFlowNoise ratioCilia-driven fluid flowMeasurementsFlow imagingCorrelation-based approachSmartphone-based diagnostic for preeclampsia: an mHealth solution for administering the Congo Red Dot (CRD) test in settings with limited resources
Jonas SM, Deserno TM, Buhimschi CS, Makin J, Choma MA, Buhimschi IA. Smartphone-based diagnostic for preeclampsia: an mHealth solution for administering the Congo Red Dot (CRD) test in settings with limited resources. Journal Of The American Medical Informatics Association 2015, 23: 166-173. PMID: 26026158, PMCID: PMC7814923, DOI: 10.1093/jamia/ocv015.Peer-Reviewed Original ResearchCitationsAltmetricQuantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology
Huang BK, Gamm UA, Jonas S, Khokha MK, Choma MA. Quantitative optical coherence tomography imaging of intermediate flow defect phenotypes in ciliary physiology and pathophysiology. Journal Of Biomedical Optics 2015, 20: 030502-030502. PMID: 25751026, PMCID: PMC4352652, DOI: 10.1117/1.jbo.20.3.030502.Peer-Reviewed Original ResearchCitationsAltmetricLow spatial coherence electrically pumped semiconductor laser for speckle-free full-field imaging
Redding B, Cerjan A, Huang X, Lee ML, Stone AD, Choma MA, Cao H. Low spatial coherence electrically pumped semiconductor laser for speckle-free full-field imaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1304-1309. PMID: 25605946, PMCID: PMC4321308, DOI: 10.1073/pnas.1419672112.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLow spatial coherenceFull-field imagingLight-emitting diodesSpatial coherenceSemiconductor lasersLaser sourceLight sourceConventional laser sourcesThermal light sourceIncoherent light sourceHigh spectral radianceIndependent spatial modesCavity laserLaser resonatorCoherent artifactsSample illuminationSpatial modesProjection applicationsIllumination sourceLaserEmitting diodesOrders of magnitudeSpectral radianceThermal sourceHigh power
2014
Microscale imaging of cilia-driven fluid flow
Huang BK, Choma MA. Microscale imaging of cilia-driven fluid flow. Cellular And Molecular Life Sciences 2014, 72: 1095-1113. PMID: 25417211, PMCID: PMC4605231, DOI: 10.1007/s00018-014-1784-z.Peer-Reviewed Original ResearchCitationsAltmetricResolving directional ambiguity in dynamic light scattering-based transverse motion velocimetry in optical coherence tomography.
Huang BK, Choma MA. Resolving directional ambiguity in dynamic light scattering-based transverse motion velocimetry in optical coherence tomography. Optics Letters 2014, 39: 521-4. PMID: 24487855, PMCID: PMC4174353, DOI: 10.1364/ol.39.000521.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTotal transverseDirectional velocityFunction calibrationTomography approachDirectional ambiguityScan axisDirectional velocity componentsThree-component velocimetryOptical coherence tomographyTransverse planeVelocity componentsLongitudinal angleCoherence tomographyDoppler velocimetryVelocimetryTransversePlane
2013
A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface
Jonas S, Zhou E, Deniz E, Huang B, Chandrasekera K, Bhattacharya D, Wu Y, Fan R, Deserno TM, Khokha MK, Choma MA. A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface. Lab On A Chip 2013, 13: 4160-4163. PMID: 23970350, PMCID: PMC3856250, DOI: 10.1039/c3lc50571e.Peer-Reviewed Original ResearchCitationsAltmetric
2012
Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography.
Deniz E, Jonas S, Khokha M, Choma MA. Endogenous contrast blood flow imaging in embryonic hearts using hemoglobin contrast subtraction angiography. Optics Letters 2012, 37: 2979-81. PMID: 22825198, PMCID: PMC3881542, DOI: 10.1364/ol.37.002979.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCongenital heart diseaseBiomechanical phenotypingSmall animal modelsMicroangiography techniqueCardiac dysfunctionEmbryonic heartHeart diseaseCardiac performanceEndogenous hemoglobin contrastContrast angiographyBlood flowCardioactive drugsAnimal modelsSubtraction angiographyVivo assessmentFunctional optical imagingHemoglobin contrastMalformed heartsAngiographyFlow imagingHeartPhysiological responsesImagingDysfunctionPhenotyping
Academic Achievements & Community Involvement
honor Numenta Startup Prize
National AwardDetails07/15/2015United Stateshonor Theodore von Kármán Fellowship, RWTH Aachen University (Germany)
International AwardDetails01/15/2014Germany
News & Links
Media
- Dye angiography of blood flowing through the larval fruit fly cardiovascular system. The dye starts in the heart (top panel) and then travels through the aorta toward the head (lower panels).
- Doppler optical coherence tomography imaging of a larval fruit fly heart. This can be thought of as to optical echocardiography. The heart has a diameter of about 100 micrometers, which is about the diameter of a human hair.
- Particle pathline imaging of cilia-driven fluid flow. The ciliated skin of the embryo (bottom of the image) generates complex flow patterns that are visualized using flow tracer microspheres.
- Microfluidic mixing driven by a biological ciliated surface, in this case, a tadpole embryo.
- Decrease in embryo heart performance as ascertained using a novel optical imaging method developed in our lab.
News
- November 18, 2024
‘Bias in, bias out’: Tackling bias in medical artificial intelligence
- June 08, 2016Source: Triple Ring Technologies
SPECKLE, CILIA, TREADMILLS, AND FALLING ELEPHANTS
- May 18, 2016Source: wtnh.com
New laser imaging system developed by Yale Researchers
- April 13, 2016
New laser gets to the heart of imaging
Related Links
- In a new research paper, Dr. Michael A. Choma and colleagues describe a new way of quantifying the ability of ciliated surfaces to drive flow
- New laser could upgrade the images in tomorrow’s technology
- Researchers work to improve health of premature babies (WTNH News Story)
- Winner Of HTM Contest At Yale
- With random lasers, Yale researchers fight random noise, improve imaging
- Yale Professor Michael Choma Wins $10,000 Numenta Startup Prize
Get In Touch
Contacts
Radiology & Biomedical Imaging
TAC N117, PO BOX 208043
New Haven, CT 06520-8043
United States