2024
Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP
Zhou Y, Wilks M, Dhaynaut M, Guehl N, Vesper D, Moon S, Rice P, El Fakhri G, Normandin M, Brugarolas P. Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP. EJNMMI Research 2024, 14: 43. PMID: 38683467, PMCID: PMC11058135, DOI: 10.1186/s13550-024-01092-8.Peer-Reviewed Original ResearchRadiation dosimetryAverage effective doseWhole-body biodistributionTotal scan timeNon-decayEffective doseNon-human primatesSymptomatic treatment of multiple sclerosisIn vivo binding affinityBed positionTreatment of multiple sclerosisHigh-resolution CTDynamic acquisition protocolDosimetryPET dataAdult rhesus macaquesScan timeImaging demyelinationOLINDA softwareRadiationAcquisition protocolsPreclinical studiesNo significant changesHigh dosesPET imaging
2013
A receptor-based model for dopamine-induced fMRI signal
Mandeville J, Sander C, Jenkins B, Hooker J, Catana C, Vanduffel W, Alpert N, Rosen B, Normandin M. A receptor-based model for dopamine-induced fMRI signal. NeuroImage 2013, 75: 46-57. PMID: 23466936, PMCID: PMC3683121, DOI: 10.1016/j.neuroimage.2013.02.036.Peer-Reviewed Original ResearchConceptsDopamine releaseFMRI dataNon-human primatesLevels of dopamine releaseD2-like receptor familyElevated synaptic dopamineSynaptic dopamineAmphetamine stimulationDopaminergic stimulationFMRINeuroimaging techniquesDopamine effectsFMRI modelFMRI signalsDopamineReceptor densityReceptor occupancyBasal gangliaLow dosesHigh dosesPre-clinical dataNeuroadaptationsRacloprideAmphetamineFunction excitation