Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases
Tong J, Chen B, Tan P, Kurpiewski S, Cai Z. Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases. Frontiers In Medicine 2022, 9: 1062432. PMID: 36438061, PMCID: PMC9685622, DOI: 10.3389/fmed.2022.1062432.Peer-Reviewed Original ResearchPositron emission tomographyCentral nervous systemCNS diseaseNeurological disordersCentral nervous system diseaseNoninvasive positron emission tomographyNervous system diseasesIntense DNA damagePlausible therapeutic targetTherapeutic responseInflammatory responseSystem diseasesTherapeutic targetNervous systemNeurological diseasesEmission tomographyDiseasePARP1/2 inhibitorsPoly (ADP-ribose) polymeraseExpression levelsImaging targetsDisordersDNA damagePARP1/2InflammationPET Imaging in Animal Models of Alzheimer’s Disease
Chen B, Marquez-Nostra B, Belitzky E, Toyonaga T, Tong J, Huang Y, Cai Z. PET Imaging in Animal Models of Alzheimer’s Disease. Frontiers In Neuroscience 2022, 16: 872509. PMID: 35685772, PMCID: PMC9171374, DOI: 10.3389/fnins.2022.872509.Peer-Reviewed Original ResearchAnimal modelsPreclinical PET imagingPET imagingOngoing clinical trialsΒ-amyloid plaquesAnimal model developmentPathogenesis/progressionTau-PETClinical trialsTau tanglesTherapeutic effectAD modelNovel treatmentsAlzheimer's diseaseDrug action mechanismsDiseaseAction mechanismImagingPatientsPETPlaquesProgressionTrialsAntemortem