Jie Tong, PhD
Associate Research ScientistCards
About
Research
Publications
2022
Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases
Tong J, Chen B, Tan P, Kurpiewski S, Cai Z. Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases. Frontiers In Medicine 2022, 9: 1062432. PMID: 36438061, PMCID: PMC9685622, DOI: 10.3389/fmed.2022.1062432.Peer-Reviewed Original ResearchPositron emission tomographyCentral nervous systemCNS diseaseNeurological disordersCentral nervous system diseaseNoninvasive positron emission tomographyNervous system diseasesIntense DNA damagePlausible therapeutic targetTherapeutic responseInflammatory responseSystem diseasesTherapeutic targetNervous systemNeurological diseasesEmission tomographyDiseasePARP1/2 inhibitorsPoly (ADP-ribose) polymeraseExpression levelsImaging targetsDisordersDNA damagePARP1/2InflammationPET Imaging in Animal Models of Alzheimer’s Disease
Chen B, Marquez-Nostra B, Belitzky E, Toyonaga T, Tong J, Huang Y, Cai Z. PET Imaging in Animal Models of Alzheimer’s Disease. Frontiers In Neuroscience 2022, 16: 872509. PMID: 35685772, PMCID: PMC9171374, DOI: 10.3389/fnins.2022.872509.Peer-Reviewed Original ResearchAnimal modelsPreclinical PET imagingPET imagingOngoing clinical trialsΒ-amyloid plaquesAnimal model developmentPathogenesis/progressionTau-PETClinical trialsTau tanglesTherapeutic effectAD modelNovel treatmentsAlzheimer's diseaseDrug action mechanismsDiseaseAction mechanismImagingPatientsPETPlaquesProgressionTrialsAntemortemP-278 Development and preliminary evaluation of the fluorine-18 labeled benzamido-dihydroindene derivative [18F]FBAIN as a potential radiotracer for PET imaging of the chemokine receptor CXCR5
Lindemann M, Tong J, Chen B, Kranz M, Oteiza A, Martin-Armas M, Sadasivam P, Drake L, Liu M, Spencer E, Huang Y, Cai Z. P-278 Development and preliminary evaluation of the fluorine-18 labeled benzamido-dihydroindene derivative [18F]FBAIN as a potential radiotracer for PET imaging of the chemokine receptor CXCR5. Nuclear Medicine And Biology 2022, 108: s200-s201. DOI: 10.1016/s0969-8051(22)00414-0.Peer-Reviewed Original ResearchP-304 The synthesis and bioevaluation of a novel and brain penetrable PARP1 tracer [18F]Pamiparib in rodents and nonhuman primates
Tong J, Chen B, Gu J, Alluri S, Zheng M, Zheng C, Felchner Z, Gao H, Zhang L, Kapinos M, Labaree D, Ropchan J, Nabulsi N, Carson R, Huang Y, Cai Z. P-304 The synthesis and bioevaluation of a novel and brain penetrable PARP1 tracer [18F]Pamiparib in rodents and nonhuman primates. Nuclear Medicine And Biology 2022, 108: s214-s215. DOI: 10.1016/s0969-8051(22)00440-1.Peer-Reviewed Original ResearchP-303 Synthesis and preclinical evaluation of PD-L1 PET tracer [18F]FDHPA in mice
Tong J, Chen B, Alluri S, Gu J, Zheng M, Zheng C, Felchner Z, Gao H, Zhang L, Kapinos M, Labaree D, Ropchan J, Nabulsi N, Marquez-Nostra B, Carson R, Huang Y, Cai Z. P-303 Synthesis and preclinical evaluation of PD-L1 PET tracer [18F]FDHPA in mice. Nuclear Medicine And Biology 2022, 108: s214. DOI: 10.1016/s0969-8051(22)00439-5.Peer-Reviewed Original Research
2021
A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [18F]SDM-16
Zheng C, Holden D, Zheng MQ, Pracitto R, Wilcox KC, Lindemann M, Felchner Z, Zhang L, Tong J, Fowles K, Finnema SJ, Nabulsi N, Carson RE, Huang Y, Cai Z. A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [18F]SDM-16. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 49: 1482-1496. PMID: 34761284, PMCID: PMC8940841, DOI: 10.1007/s00259-021-05597-5.Peer-Reviewed Original ResearchConceptsTest-retest variabilityVolume of distributionCentral nervous systemTime-activity curvesPET tracersCentrum semiovaleSynaptic vesicle protein 2AAbsolute test-retest variabilityWhole central nervous systemNonhuman primate brainPlasma free fractionBrain PET scansHigh specific bindingSpecific bindingNondisplaceable volumePlasma input functionNHP brainOne-tissue compartment modelArterial bloodRegional time-activity curvesPET scansNervous systemPrimate brainMonkey brainPreclinical characterizationFurther Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and Structure–Activity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones
Pracitto R, Wilcox KC, Lindemann M, Tong J, Zheng C, Li S, Finnema SJ, Huang Y, Cai Z. Further Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and Structure–Activity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones. ACS Omega 2021, 6: 27676-27683. PMID: 34722967, PMCID: PMC8552234, DOI: 10.1021/acsomega.1c02433.Peer-Reviewed Original Research