2024
NIMG-30. DEUTERIUM METABOLIC IMAGING (DMI) SHOWS A STRONG RELATION BETWEEN TUMOR GRADE AND GLUCOSE METABOLISM IN PRIMARY BRAIN TUMORS
Thaw-Poon S, Blondin N, Liu Y, Corbin Z, Baehring J, Omuro A, Moliterno J, Omay S, Fulbright R, de Graaf R, De Feyter H. NIMG-30. DEUTERIUM METABOLIC IMAGING (DMI) SHOWS A STRONG RELATION BETWEEN TUMOR GRADE AND GLUCOSE METABOLISM IN PRIMARY BRAIN TUMORS. Neuro-Oncology 2024, 26: viii201-viii201. PMCID: PMC11553074, DOI: 10.1093/neuonc/noae165.0795.Peer-Reviewed Original ResearchGrade 2 lesionsTumor gradeDeuterium metabolic imagingMetabolic imagingNon-enhancing tumor regionsBrain tumorsTumor-to-brain contrastTumour-specific valuesActive tumor tissueImage contrastVOI-based analysisGrade 4Evaluate disease progressionTesla MRI scannerFDG-PETGrade 3Lesion gradeTumor tissuesDisease progressionDisease stageOral administrationTumorObservational studyNormal brainContrast enhancementNIMG-32. ORAL ADMINISTRATION OF DEUTERATED CHOLINE AS A NEW APPROACH TO PROVIDE HIGH TUMOR-TO-BRAIN IMAGE CONTRAST IN DEUTERIUM METABOLIC IMAGING (DMI)
Osoliniec V, Thomas M, de Graaf R, De Feyter H. NIMG-32. ORAL ADMINISTRATION OF DEUTERATED CHOLINE AS A NEW APPROACH TO PROVIDE HIGH TUMOR-TO-BRAIN IMAGE CONTRAST IN DEUTERIUM METABOLIC IMAGING (DMI). Neuro-Oncology 2024, 26: viii202-viii202. PMCID: PMC11552881, DOI: 10.1093/neuonc/noae165.0797.Peer-Reviewed Original ResearchTumor-to-brain contrastOral administrationMetabolic imagingDeuterium metabolic imagingIV infusionTCho concentrationOrthotopic models of glioblastomaNormal brainContralateral normal brainTumor-to-brainDays of oral administrationModels of glioblastomaAdministration of cholineTesla MRI scannerTCho signalMg/kg body weightOrthotopic modelFDG-PETOral administration of cholineTotal cholineDaily doseIntravenous infusionF344 ratsTail veinCholine metabolites
2023
Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)
Ip K, Thomas M, Behar K, de Graaf R, De Feyter H. Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI). Frontiers In Cellular Neuroscience 2023, 17: 1130816. PMID: 37187610, PMCID: PMC10175635, DOI: 10.3389/fncel.2023.1130816.Peer-Reviewed Original ResearchBrain tumorsNormal brainHigh tumorCholine uptakeRG2 cellsCholine infusionMetabolic imagingExogenous cholineMetabolic imaging techniquesDeuterium metabolic imagingIntravenous infusionRG2 tumorsTumor lesionsAnimal modelsCholine metabolismTumorsInfusionRat glioblastomaIntracellular cholineFree cholineHigh uptakeLesionsCholineRatsDeuterated choline
2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances 2018, 4: eaat7314. PMID: 30140744, PMCID: PMC6105304, DOI: 10.1126/sciadv.aat7314.Peer-Reviewed Original ResearchConceptsOral intakeMetabolic imagingGlucose uptakeHigh-grade brain tumorsRat glioma modelPositron emission tomography (PET) detectionSimilar metabolic patternMetabolic imaging techniquesDeuterium metabolic imagingHigher glucose uptakeGlucose analog 2FDG-PETF-fluoroIntravenous infusionBrain tumorsGlioma modelGlucose metabolismNormal brainTomography detectionAnimal modelsMagnetic resonance spectroscopicTumor tissueHuman liverMetabolic patternsNoninvasive approach