2016
Periventricular hyperintensities are associated with elevated cerebral amyloid
Marnane M, Al-Jawadi OO, Mortazavi S, Pogorzelec KJ, Wang BW, Feldman HH, Hsiung GY, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha D, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Periventricular hyperintensities are associated with elevated cerebral amyloid. Neurology 2016, 86: 535-543. PMID: 26747881, PMCID: PMC4753726, DOI: 10.1212/wnl.0000000000002352.Peer-Reviewed Original ResearchConceptsVascular risk factorsCerebral amyloidLogistic regression modelsMild cognitive impairmentCSF AβRisk factorsDisease Neuroimaging InitiativeProspective multicenter observational studyFluid-attenuated inversion recovery MRICerebral β-amyloidCSF Aβ levelsMulticenter observational studySecondary prevention medicationsSemiquantitative visual rating scalesLow CSF AβAgreement intraclass correlation coefficientsInversion recovery MRIVisual rating scaleIntraclass correlation coefficientAlzheimer's Disease Neuroimaging InitiativeCSF-phosphoCerebral hypometabolismPrevention medicationsPeriventricular hyperintensityRegression models
1999
Structural brain imaging in schizophrenia: a selective review
Pearlson G, Marsh L. Structural brain imaging in schizophrenia: a selective review. Biological Psychiatry 1999, 46: 627-649. PMID: 10472416, DOI: 10.1016/s0006-3223(99)00071-2.Peer-Reviewed Original ResearchMeSH KeywordsBrainCerebral VentriclesFemaleHumansMagnetic Resonance ImagingMaleSchizophreniaSensitivity and SpecificityConceptsStructural neuroimaging studiesRegional brain volume abnormalitiesBrain structuresNeuroimaging studiesLateral ventricular enlargementPathophysiology of schizophreniaAbnormal brain structureBrain volume abnormalitiesComputed tomography studyNeuroanatomic pathologyVentricular enlargementBrain abnormalitiesAnatomic findingsVolume abnormalitiesStructural brainSchizophreniaTomography studySelective reviewAbnormalitiesConsistent evidenceBrainGenetic influencesReviewPathophysiologyFindings
1997
Small planum temporale volume in Down's syndrome: a volumetric MRI study
Frangou S, Aylward E, Warren A, Sharma T, Barta P, Pearlson G. Small planum temporale volume in Down's syndrome: a volumetric MRI study. American Journal Of Psychiatry 1997, 154: 1424-1429. PMID: 9326826, DOI: 10.1176/ajp.154.10.1424.Peer-Reviewed Original ResearchConceptsPlanum temporale volumeSuperior temporal gyrusDown syndromeTemporal gyrusSyndrome patientsBrain volumePlanum temporaleMagnetic resonance imaging (MRI) measuresCommunity-dwelling patientsStructural brain abnormalitiesVolumetric MRI studyTotal brain volumeDown syndrome patientsHealthy comparison subjectsWhole brain volumeVolumetric magnetic resonance imaging (MRI) measuresAnatomic substrateBrain abnormalitiesHealthy subjectsComparison subjectsMRI studiesVolume deficitsSyndromeGyrusImaging measures
1992
Magnetic resonance imaging in autism: measurement of the cerebellum, pons, and fourth ventricle
Piven J, Nehme E, Simon J, Barta P, Pearlson G, Folstein S. Magnetic resonance imaging in autism: measurement of the cerebellum, pons, and fourth ventricle. Biological Psychiatry 1992, 31: 491-504. PMID: 1581425, DOI: 10.1016/0006-3223(92)90260-7.Peer-Reviewed Original Research
1991
Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography
Cascella N, Pearlson G, Wong D, Broussolle E, Nagoshi C, Margolin R, London E. Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography. The British Journal Of Psychiatry 1991, 159: 217-221. PMID: 1773237, DOI: 10.1192/bjp.159.2.217.Peer-Reviewed Original ResearchConceptsSubstance abuseSulcal measuresCocaine useSulcal widthWider third ventriclesEffect of ageBrain atrophyBrain ratioChronic useComputerised tomographyThird ventricleNormal controlsAlcohol consumptionBrain morphologyAlcohol usePolydrug abusersSignificant predictorsAgeVentricleSeverityTomographyPositive correlationAbusePossible effectsVentricular
1987
Increased ventricle-to-brain ratio in late-onset schizophrenia
Rabins P, Pearlson G, Jayaram G, Steele C, Tune L. Increased ventricle-to-brain ratio in late-onset schizophrenia. American Journal Of Psychiatry 1987, 144: 1216-1218. PMID: 3631322, DOI: 10.1176/ajp.144.9.1216.Peer-Reviewed Original Research
1985
Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars
PEARLSON G, GARBACZ D, MOBERG P, AHN H, DEPAULO J. Symptomatic, Familial, Perinatal, and Social Correlates of Computerized Axial Tomography (CAT) Changes in Schizophrenics and Bipolars. The Journal Of Nervous And Mental Disease 1985, 173: 42-50. PMID: 3965611, DOI: 10.1097/00005053-198501000-00007.Peer-Reviewed Original ResearchConceptsVentricular enlargementFamily historyNegative symptomsComputerized axial tomography scanLateral ventricular enlargementAxial tomography scanPast psychiatric historyEarly brain damageMarked ventricular enlargementSubgroup of schizophrenicsPoor premorbid adjustmentLateral ventricularTomography changesBrain ratioPatient groupBrain damageTomography scanPsychiatric illnessPsychiatric historyBipolar patientsNormal controlsEarly onsetPatientsPremorbid adjustmentSignificant proportion
1984
Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder
Pearlson G, Garbacz D, Breakey W, Ahn H, DePaulo J. Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Research 1984, 12: 1-9. PMID: 6589656, DOI: 10.1016/0165-1781(84)90133-1.Peer-Reviewed Original Research