2018
T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY
Guimond S, Tingue S, Devenyi G, Tang Y, Mike L, Chakravarty M, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY. Schizophrenia Bulletin 2018, 44: s121-s121. PMCID: PMC5888564, DOI: 10.1093/schbul/sby016.298.Peer-Reviewed Original ResearchPituitary gland volumeLarger pituitary glandsDuration of illnessHealthy controlsGland volumePituitary glandPsychotic bipolar disorderSymptom severityBipolar-Schizophrenia NetworkPituitary volumeSchizoaffective disorderLarger pituitary gland volumesClinical diagnosisLarger pituitary volumeSubgroup of patientsSignificant main effectGreater symptom severitySignificant subgroup differencesIndependent t-testAdrenal axisPatient groupIntermediate Phenotypes (B-SNIP) consortiumMAGeT Brain algorithmStructural magnetic resonance imagesIntermediate Phenotypes (B-SNIP) study
2014
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
Meda SA, Ruaño G, Windemuth A, O’Neil K, Berwise C, Dunn SM, Boccaccio LE, Narayanan B, Kocherla M, Sprooten E, Keshavan MS, Tamminga CA, Sweeney JA, Clementz BA, Calhoun VD, Pearlson GD. Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e2066-e2075. PMID: 24778245, PMCID: PMC4024891, DOI: 10.1073/pnas.1313093111.Peer-Reviewed Original ResearchConceptsDefault mode networkPsychotic bipolar disorderUnaffected first-degree relativesFirst-degree relativesSZ probandsResting-state functional MRI scansBipolar disorderMode networkFunctional MRI scansLong-term potentiationBrain's default mode networkGlobal enrichment analysisSubset of controlsPatient groupHealthy controlsDMN modulationDrug treatmentImmune responsePsychiatric disordersStudy subjectsMRI scansDMN connectivityMultivariate analysisFunctional connectivitySchizophrenia
1995
In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder
Pearlson G, Wong D, Tune L, Ross C, Chase G, Links J, Dannals R, Wilson A, Ravert H, Wagner H, DePaulo J. In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder. JAMA Psychiatry 1995, 52: 471-477. PMID: 7771917, DOI: 10.1001/archpsyc.1995.03950180057008.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsBipolar disorderBmax valuesNonpsychotic patientsNormal controlsPsychotic symptomsPsychotic patientsAffective disordersPositron emission tomographic scansD2 dopamine receptor densityNeuroleptic-naive schizophrenic patientsPositron emission tomographic studiesDopamine receptor densityReceptor density valuesDSM-III criteriaPresent State ExaminationPresence of psychosisEmission tomographic studiesHigher Bmax valuesPsychotic bipolar disorderNeuroleptic medicationReceptor BmaxMood abnormalitiesReceptor valuesTomographic scan