1995
In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder
Pearlson G, Wong D, Tune L, Ross C, Chase G, Links J, Dannals R, Wilson A, Ravert H, Wagner H, DePaulo J. In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder. JAMA Psychiatry 1995, 52: 471-477. PMID: 7771917, DOI: 10.1001/archpsyc.1995.03950180057008.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsBipolar disorderBmax valuesNonpsychotic patientsNormal controlsPsychotic symptomsPsychotic patientsAffective disordersPositron emission tomographic scansD2 dopamine receptor densityNeuroleptic-naive schizophrenic patientsPositron emission tomographic studiesDopamine receptor densityReceptor density valuesDSM-III criteriaPresent State ExaminationPresence of psychosisEmission tomographic studiesHigher Bmax valuesPsychotic bipolar disorderNeuroleptic medicationReceptor BmaxMood abnormalitiesReceptor valuesTomographic scan
1984
NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY
Lipsey J, Pearlson G, Robinson R, Rao K, Price T. NORTRIPTYLINE TREATMENT OF POST-STROKE DEPRESSION: A DOUBLE-BLIND STUDY. The Lancet 1984, 323: 297-300. PMID: 6141377, DOI: 10.1016/s0140-6736(84)90356-8.Peer-Reviewed Original ResearchConceptsPost-stroke depressionDouble-blind studyDepression ScaleEfficacy of nortriptylinePlacebo-treated patientsSerum nortriptyline levelsHamilton Depression ScalePresent State ExaminationZung Depression ScaleStroke patientsTherapeutic rangeMajor depressionNortriptyline levelsDemonstrated efficacyState ExaminationPatientsNortriptylineDepressionGreater improvementTreatmentSimilar groupsEfficacyImportant addition