2020
O3.4. PSYCHOSIS PHENOTYPES FROM B-SNIP FOR CLINICAL ADVANCES: BIOTYPE CHARACTERISTICS AND TARGETS
Clementz B, Trotti R, Pearlson G, Keshavan M, Gershon E, Keedy S, Ivleva E, McDowell J, Tamminga C. O3.4. PSYCHOSIS PHENOTYPES FROM B-SNIP FOR CLINICAL ADVANCES: BIOTYPE CHARACTERISTICS AND TARGETS. Schizophrenia Bulletin 2020, 46: s7-s7. PMCID: PMC7234003, DOI: 10.1093/schbul/sbaa028.015.Peer-Reviewed Original ResearchClinical featuresPsychosis biotypesPsychosis casesPsychosis syndromeTreatment targetsSpecific treatment targetsB-SNIPClinical manifestationsBiomarker profilesPsychosis subgroupsB-SNIP consortiumDeep phenotyping approachPathophysiological mechanismsPsychosis patientsBipolar-Schizophrenia NetworkPsychosis diagnosisBiological subtypesHealthy personsClinical practiceClinical advancesNegative symptomsClinical phenomenologySyndrome
2019
Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium
Thomas O, Parker D, Trotti R, McDowell J, Gershon E, Sweeney J, Keshavan M, Keedy S, Ivleva E, Tamminga C, Pearlson G, Clementz B. Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium. Biomarkers In Neuropsychiatry 2019, 1: 100002. PMID: 36643612, PMCID: PMC9837786, DOI: 10.1016/j.bionps.2019.100002.Peer-Reviewed Original ResearchPsychosis biotypesHealthy personsBipolar-Schizophrenia NetworkSingle-trial powerFirst-degree biological relativesNeural activity differencesInter-stimulus intervalBiotype 2Intermediate Phenotypes (B-SNIP) consortiumPsychosis casesEffective treatmentIntrinsic activityPsychosis subgroupsNeural modulationLow intrinsic activityDSM groupNeural activitySocial functioningBiotype characterizationBiological relativesConventional diagnosisIntermediate phenotypesDifferentiating featuresDSM syndromesProbands
2018
9.3 PSYCHOSIS BIOTYPES VERSUS CLINICAL SYNDROMES THROUGH THE PRISM OF INTRINSIC NEURAL ACTIVITY
Clementz B, Pearlson G, Tamminga C, Sweeney J, Keshavan M. 9.3 PSYCHOSIS BIOTYPES VERSUS CLINICAL SYNDROMES THROUGH THE PRISM OF INTRINSIC NEURAL ACTIVITY. Schizophrenia Bulletin 2018, 44: s14-s14. PMCID: PMC5888365, DOI: 10.1093/schbul/sby014.031.Peer-Reviewed Original ResearchInter-trial intervalNeural activityIntrinsic neural activityPsychosis biotypesDSM diagnosesSingle-trial powerOngoing neural activityBipolar-Schizophrenia NetworkHealthy personsStimulus salienceNeural responsesNeural oscillationsB-SNIPNeurobiological similaritiesNeurophysiological modelFirst-degree relativesEEG measuresTreatment developmentSensory cortexTranslational research programClinical featuresDistinct physiological mechanismsHealthy groupPsychosis diagnosisPsychosis cases