2024
Cerebral Blood Flow Changes and Neuroticism in Late-Life Depression
Anderson T, Steffens D, Wang L, Pearlson G. Cerebral Blood Flow Changes and Neuroticism in Late-Life Depression. American Journal Of Geriatric Psychiatry 2024, 32: s49-s50. DOI: 10.1016/j.jagp.2024.01.121.Peer-Reviewed Original ResearchMontgomery Asberg Depression Rating ScaleLate-life depressionAsberg Depression Rating ScaleLeft putamenFrontal poleLow neuroticismGroup differencesDecreased CBFLLD subjectsDepression severityDepression groupLLD groupCerebral blood flowNever-depressed control subjectsNever-depressed healthy controlsNEO Personality InventoryNever-depressed groupDepression Rating ScaleNeuroticism personality traitFrontal lobe structuresGroup effectBrain morphological changesT1-weighted MPRAGE imagesHealthy controlsSignificant group effect
2023
Association between perceived stress and brain structure volumes in older adults without late-life depression: a key role for the thalamus?
Anam A, Wang L, Pearlson G. Association between perceived stress and brain structure volumes in older adults without late-life depression: a key role for the thalamus? American Journal Of Geriatric Psychiatry 2023, 31: s61-s62. DOI: 10.1016/j.jagp.2022.12.221.Peer-Reviewed Original ResearchLate-life depressionThalamus volumeEarly life stressHC groupLLD groupPrefrontal cortexOlder adultsAnterior cingulateBrain volumeControl groupDuke Depression Evaluation ScheduleMontgomery-Asberg Depression Rating ScaleSimilar findingsHealthy control subjectsDepression Rating ScaleIntracranial brain volumeSignificant differencesSignificant correlationConnecticut Health CenterDorsal anterior cingulateSubcortical brain regionsStandardized acquisition protocolBrain structure volumesVentral anterior cingulateInstitutional review board
2019
Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression
Emam H, Steffens DC, Pearlson G, Wang L. Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression. International Journal Of Geriatric Psychiatry 2019, 34: 730-737. PMID: 30761621, PMCID: PMC6480406, DOI: 10.1002/gps.5079.Peer-Reviewed Original ResearchConceptsLate-life depressionSelective serotonin reuptake inhibitorsNonresponder groupFunctional connectivitySSRI responseMADRS scoresResting-state functional magnetic resonance imaging (fMRI) scansMontgomery-Åsberg Depression Rating ScaleMajor depressive disorder patientsPrefrontal cortexMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansSubgenual cingulate areaSerotonin reuptake inhibitorsDepressive disorder patientsAcute treatment responseResonance imaging scansDepression Rating ScaleLower functional connectivityHigher functional connectivityFalse discovery rate correctionResting-state activityDefault mode networkROI connectivityAntidepressant treatment