2023
Characterization of childhood trauma, hippocampal mediation and Cannabis use in a large dataset of psychosis and non-psychosis individuals
Del Re E, Yassin W, Zeng V, Keedy S, Alliey-Rodriguez N, Ivleva E, Hill S, Rychagov N, McDowell J, Bishop J, Mesholam-Gately R, Merola G, Lizano P, Gershon E, Pearlson G, Sweeney J, Clementz B, Tamminga C, Keshavan M. Characterization of childhood trauma, hippocampal mediation and Cannabis use in a large dataset of psychosis and non-psychosis individuals. Schizophrenia Research 2023, 255: 102-109. PMID: 36989667, DOI: 10.1016/j.schres.2023.03.029.Peer-Reviewed Original ResearchConceptsChildhood Trauma QuestionnaireChildhood traumaPsychosis onsetBipolar disorder type 1Rich brain regionsAbuse/dependenceHigh childhood traumaSevere childhood traumaPolygenic risk scoresRisk scoreClinical interviewersSchizoaffective disorderMulticenter sampleSurvival analysisCA exposureYounger ageBrain regionsType 1Psychosis riskLower ageCeiling effectsHippocampusTrauma QuestionnaireSZ-polygenic risk scoreGenetic risk
2020
T67. TRAUMA IN AFFECTIVE AND NONAFFECTIVE PSYCHOSIS: ASSOCIATIONS AND DISSOCIATIONS WITH COGNITIVE FUNCTIONING IN CHILDHOOD AND ADULTHOOD
Mollon J, Knowles E, Mathias S, Rodrigue A, Koenis M, Pearlson G, Glahn D. T67. TRAUMA IN AFFECTIVE AND NONAFFECTIVE PSYCHOSIS: ASSOCIATIONS AND DISSOCIATIONS WITH COGNITIVE FUNCTIONING IN CHILDHOOD AND ADULTHOOD. Schizophrenia Bulletin 2020, 46: s256-s257. PMCID: PMC7234213, DOI: 10.1093/schbul/sbaa029.627.Peer-Reviewed Original ResearchAffective psychosis groupNon-psychotic psychiatric disordersPsychotic disordersAdult traumaPsychosis groupChildhood Trauma QuestionnaireChildhood traumaTrauma History QuestionnairePsychiatric disordersCognitive functioningLifetime traumaImportant risk factorCase-control studyNonaffective psychotic disordersNon-psychotic groupAffective psychotic disordersManifestation of psychosisChildhood neglectAfrican American adultsNeurodevelopmental impairmentMore lifetime traumasRisk factorsAffective psychosisNonaffective psychosisHistory questionnaire