2021
In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker
Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin M, Fakhri G, Brownell A. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Scientific Reports 2021, 11: 15897. PMID: 34354107, PMCID: PMC8342610, DOI: 10.1038/s41598-021-94967-y.Peer-Reviewed Original ResearchConceptsFragile X syndromeFragile X mental retardation proteinX syndromeLoss of fragile X mental retardation proteinMGlu5 receptor expressionMetabotropic glutamate subtype 5 receptorsDrug occupancy studiesSignificant group differencesFragile X mental retardationHealthy controlsAnterior cingulateMGluR5 availabilityVisuospatial processingMGlu5 receptorsOlfactory cortexBrain areasGroup differencesRetardation proteinGlutamate signalingImages of maleNeurodevelopmental disordersExcessive glutamate signalingGender-matched controlsDisordersMGluR5
2017
Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children
Ortiz-Terán L, Diez I, Ortiz T, Perez D, Aragón J, Costumero V, Pascual-Leone A, Fakhri G, Sepulcre J. Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 6830-6835. PMID: 28607055, PMCID: PMC5495230, DOI: 10.1073/pnas.1619121114.Peer-Reviewed Original ResearchMeSH KeywordsBlindnessChildFemaleGene Expression RegulationHumansMaleNerve NetNerve Tissue ProteinsNeuronal PlasticitySomatosensory CortexConceptsBlind childrenFunctional connectivity analysisMultisensory integration areasSensory deprivationFunctional connectivity relationshipsProtein gene familyNetwork connectivity profilesPrimary sensory cortexSystems-level analysisNeuroplastic adaptationsMultisensory cortexFunctional connectivityConnectivity analysisHuman neuroplasticityConnectivity changesGene expression profilesConnectivity profilesNeural reorganizationSensory cortexGene familySighted controlsHuman brainCortexBiological basisGenetic underpinnings