2024
The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas
Najem E, Marin T, Zhuo Y, Lahoud R, Tian F, Beddok A, Rozenblum L, Xing F, Moteabbed M, Lim R, Liu X, Woo J, Lostetter S, Lamane A, Chen Y, Ma C, El Fakhri G. The role of 18F-FDG PET in minimizing variability in gross tumor volume delineation of soft tissue sarcomas. Radiotherapy And Oncology 2024, 194: 110186. PMID: 38412906, PMCID: PMC11042980, DOI: 10.1016/j.radonc.2024.110186.Peer-Reviewed Original ResearchGross tumor volume delineationGross tumor volumeDice similarity coefficientF-FDG PET imagingSoft tissue sarcomasInter-reader variabilityGTV delineationRadiation therapy treatment planningF-FDGF-FDG PETTherapy treatment planningPerformance level estimationTumor volume delineationTissue sarcomasPET imagingVolume delineationSimultaneous truthHausdorff distanceDice similarity coefficient scoreAccurate gross tumor volumeImaging modality groupsWilcoxon signed-rank testStatistically significant decreaseSigned-rank testTumor volume
2022
Feasibility study of clinical target volume definition for soft-tissue sarcoma using muscle fiber orientations derived from diffusion tensor imaging
Shusharina N, Liu X, Coll-Font J, Foster A, Fakhri G, Woo J, Bortfeld T, Nguyen C. Feasibility study of clinical target volume definition for soft-tissue sarcoma using muscle fiber orientations derived from diffusion tensor imaging. Physics In Medicine And Biology 2022, 67: 155013. PMID: 35817048, PMCID: PMC9344976, DOI: 10.1088/1361-6560/ac8045.Peer-Reviewed Original ResearchConceptsClinical target volumeSoft tissue sarcomasHealthy volunteersClinical target volume definitionClinical target volume delineationRight thighGross tumor volumeTarget volume definitionEcho-planar acquisitionsTarget volumeAuto-segmentationTumor volumeVolume definitionSarcoma patientsTissue sarcomasCT planeConvolutional neural networkT2-weightedCancer CenterPlanar acquisitionImaging sessionFat suppressionMR imagingSarcomaAnatomical orientation
2015
Synergistic role of simultaneous PET/MRI-MRS in soft tissue sarcoma metabolism imaging
Zhang X, Chen Y, Lim R, Huang C, Chebib I, Fakhri G. Synergistic role of simultaneous PET/MRI-MRS in soft tissue sarcoma metabolism imaging. Magnetic Resonance Imaging 2015, 34: 276-279. PMID: 26523656, PMCID: PMC4761342, DOI: 10.1016/j.mri.2015.10.027.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasMagnetic resonance imagingHigh (18)F-FDG uptakeT2 hyperintense massMagnetic resonance spectroscopyNeoadjuvant radiotherapyPathological resultsTumor marginsTissue sarcomasImaging findingsPET/MRI scansPET scansRight thighRadiotherapyNormal tissuesEmission tomographyResonance imagingMetabolite profilesSarcomaPET/MRIChemoRTChemoradiationSynergistic rolePETSurgery