2024
PET mapping of receptor occupancy using joint direct parametric reconstruction
Marin T, Belov V, Chemli Y, Ouyang J, Najmaoui Y, Fakhri G, Duvvuri S, Iredale P, Guehl N, Normandin M, Petibon Y. PET mapping of receptor occupancy using joint direct parametric reconstruction. IEEE Transactions On Biomedical Engineering 2024, PP: 1-15. PMID: 39446540, DOI: 10.1109/tbme.2024.3486191.Peer-Reviewed Original ResearchCentral nervous systemReceptor occupancyLow-binding regionsPET scansSimulation resultsPreclinical in vivo experimentsDynamic PET scansPairs of baselineEstimation of receptor occupancyEstimation frameworkPET neuroimagingReconstruction frameworkModulating drugsTime activity curvesParametric reconstructionDevelopment of drugs
2016
A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography
Zhu W, Ouyang J, Rakvongthai Y, Guehl N, Wooten D, Fakhri G, Normandin M, Fan Y. A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography. Medical Physics 2016, 43: 1222-1234. PMID: 26936707, PMCID: PMC5025019, DOI: 10.1118/1.4941010.Peer-Reviewed Original ResearchConceptsPositron emission tomographySpatial mixture modelNearby voxelsMixture modelEmission tomographyDynamic positron emission tomographyK-means methodKinetic modelKinetic parametric imagesOne-compartment kinetic modelNovel algorithmTemporal informationClassification purposesMeasurement of local perfusionLocal perfusionTime activity curvesNormal ROIsTemporal modelBayesian algorithmCardiac studiesMarkov chain Monte CarloParameter estimationNoise regionSimulation experimentsSimulated data sets
2013
Dual-Tracer PET Using Generalized Factor Analysis of Dynamic Sequences
El Fakhri G, Trott C, Sitek A, Bonab A, Alpert N. Dual-Tracer PET Using Generalized Factor Analysis of Dynamic Sequences. Molecular Imaging And Biology 2013, 15: 666-674. PMID: 23636489, PMCID: PMC3812387, DOI: 10.1007/s11307-013-0631-1.Peer-Reviewed Original ResearchConceptsEmit gamma raysPositron emission tomographyNear-simultaneous imagingSingle-photon emissionBrain PET studiesGamma raysSingle-photon emission computed tomographyActivity distributionRaclopride studiesEmission computed tomographyPositron emission tomography radiopharmaceuticalsSimultaneous imagingD2 bindingFactor analysis of dynamic sequencesActivity estimationTime activity curvesRacloprideFDGRhesus monkeysEmission tomographyPET studiesActivation curveBrain metabolismEmissionSimulate human data
2011
A Nonlocal Averaging Technique for Kinetic Parameter Estimation from Dynamic PET Data
Dutta J, Fakhri G, Leahy R, Li Q. A Nonlocal Averaging Technique for Kinetic Parameter Estimation from Dynamic PET Data. 2011, 3562-3566. DOI: 10.1109/nssmic.2011.6153669.Peer-Reviewed Original ResearchNonlocal meansDenoising schemeGaussian filtering techniquePatlak parametric imagesDenoised time seriesDenoising frameworkClustering stepDistributed natureGaussian filterLocal neighborhoodVoxel-wise estimationHigh noise levelsData setsDenoisingFiltering techniqueSchemeDataLow varianceNoise levelTime activity curvesEstimation of kinetic parametersDynamic PET imagesParameter estimationVoxelImages
2006
Simultaneous Dual Tracer PET Using Generalized Factor Analysis of Dynamic Sequences
Fakhri G, Sitek A, Guérin B. Simultaneous Dual Tracer PET Using Generalized Factor Analysis of Dynamic Sequences. 2006, 4: 2128-2130. DOI: 10.1109/nssmic.2006.354334.Peer-Reviewed Original ResearchGeneralized five‐dimensional dynamic and spectral factor analysis
Fakhri G, Sitek A, Zimmerman R, Ouyang J. Generalized five‐dimensional dynamic and spectral factor analysis. Medical Physics 2006, 33: 1016-1024. PMID: 16696478, DOI: 10.1118/1.2179168.Peer-Reviewed Original Research