2014
4D numerical observer for lesion detection in respiratory‐gated PET
Lorsakul A, Li Q, Trott C, Hoog C, Petibon Y, Ouyang J, Laine A, Fakhri G. 4D numerical observer for lesion detection in respiratory‐gated PET. Medical Physics 2014, 41: 102504. PMID: 25281979, PMCID: PMC4281099, DOI: 10.1118/1.4895975.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationFluorodeoxyglucose F18HumansImage Interpretation, Computer-AssistedLung DiseasesModels, BiologicalMonte Carlo MethodMotionPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsRegression AnalysisRespiratory-Gated Imaging TechniquesSignal-To-Noise RatioConceptsRespiratory-gated positron emission tomographyMotion-corrected imagesDetection signal-to-noise ratioLesion detection taskNumerical observationsLesion detection performanceSignal-to-noise ratioPositron emission tomography sinogramsSpherical lesionsHotelling observerMotion correction methodPositron emission tomographyGeant4 ApplicationTomographic EmissionChannelized Hotelling observerAnthropomorphic phantomScanner geometryOSEM algorithmMonte Carlo simulationsPET framesImprove lesion detectionLesion detectionSignal-to-noise ratio measurementsActivity distributionConventional 3D approach
2011
Improvement in Lesion Detection with Whole-Body Oncologic Time-of-Flight PET
Fakhri G, Surti S, Trott C, Scheuermann J, Karp J. Improvement in Lesion Detection with Whole-Body Oncologic Time-of-Flight PET. Journal Of Nuclear Medicine 2011, 52: 347-353. PMID: 21321265, PMCID: PMC3088884, DOI: 10.2967/jnumed.110.080382.Peer-Reviewed Original ResearchConceptsTime-of-flight PETTime-of-flightTOF-PETTime-of-flight reconstructionBody mass indexList-mode dataNon-TOF PETObserver signal-to-noise ratioOrdered-subset expectation maximizationMass indexNon-TOFLesion detectionLesion detection performanceSpherical lesionsFunction of body mass indexSignal-to-noise ratioScan timePatient studiesLesion visibilityArtificial lesionsLiver lesionsPatientsLesionsLesion locationLow lesions
2005
Performance of a novel collimator for high‐sensitivity brain SPECT
Fakhri G, Ouyang J, Zimmerman R, Fischman A, Kijewski M. Performance of a novel collimator for high‐sensitivity brain SPECT. Medical Physics 2005, 33: 209-215. PMID: 16485427, DOI: 10.1118/1.2143140.Peer-Reviewed Original ResearchConceptsSphere activity concentrationNPW-SNRStandard collimatorSphere-to-background activity ratiosAttenuation of countsPhantom centerActivity concentrationsPoint spread functionCentral regionCollimatorPhantom studyStriatal phantomCylindrical backgroundResolution recoveryPhantomSpherical lesionsRamp filterCrystal surfaceSpread functionSignal-to-noise ratioCentral brain structuresFitting imageHealthy volunteersBrain SPECTSphere activity