2020
Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for 13N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies
Guehl N, Pelletier-Galarneau M, Wooten D, Guerrero J, Kas A, Normandin M, Fakhri G, Alpert N. Preclinical Validation of a Single-Scan Rest/Stress Imaging Technique for 13N-Ammonia Positron Emission Tomography Cardiac Perfusion Studies. Circulation Cardiovascular Imaging 2020, 13: e009407. PMID: 31959009, PMCID: PMC7205554, DOI: 10.1161/circimaging.119.009407.Peer-Reviewed Original ResearchConceptsMyocardial blood flowPerfusion imagingMyocardial perfusion imaging proceduresSCAN-ALeft anterior descending arteryDose of adenosineAbsolute myocardial blood flowStress perfusion imagingAnterior descending arteryCardiac perfusion studiesMyocardial blood flow measurementsBland-Altman analysisNonstationary kinetic modelPositron emission tomographyMeasurement of restMyocardial blood flow valuesPharmacological stressorDescending arteryPreclinical validationMyocardial blood flow estimatesSingle-scan acquisitionPerfusion studiesVariable dosesImaging sessionMicrosphere MBF measurements
2019
Quantification of PET Myocardial Blood Flow
Pelletier-Galarneau M, Martineau P, El Fakhri G. Quantification of PET Myocardial Blood Flow. Current Cardiology Reports 2019, 21: 11. PMID: 30815744, DOI: 10.1007/s11886-019-1096-x.Peer-Reviewed Original ResearchConceptsPositron emission tomographyMyocardial blood flowMyocardial flow reserveMicrovascular dysfunctionEvaluation of cardiac allograft vasculopathyAssessment of coronary microvascular dysfunctionFlow reserveHyperemic myocardial blood flowFlow quantificationCardiac allograft vasculopathyMarkers of disease severityCoronary microvascular dysfunctionImprove risk stratificationQuantification of myocardial blood flowFractional flow reserveMyocardial blood flow quantificationAllograft vasculopathyPrognostic valueRisk stratificationEpicardial diseaseAcademic centersReviewThe aimClinical aspectsEmission tomographyBlood flow
2017
Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies
Petibon Y, Rakvongthai Y, Fakhri G, Ouyang J. Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies. Physics In Medicine And Biology 2017, 62: 3539-3565. PMID: 28379843, PMCID: PMC5739089, DOI: 10.1088/1361-6560/aa6394.Peer-Reviewed Original ResearchConceptsPET sinogramsSignal-to-noise ratioList-mode PET dataSiemens Biograph mMR scannerList-mode dataMyocardial perfusion imagingNoise realizationsPET myocardial perfusion imagingLow count levelsLeast-squares fitBiograph mMR scannerPET projection dataOriginal list-mode dataMyocardial blood flowCount levelsParametric reconstructionOSEMReconstruction methodIndependent noise realizationsNormal count levelsSinogramDirect reconstructionDynamic sinogramsKinetic modelPoor signal-to-noise ratioSingle-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz
Guehl N, Normandin M, Wooten D, Rozen G, Sitek A, Ruskin J, Shoup T, Ptaszek L, El Fakhri G, Alpert N. Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz. European Journal Of Nuclear Medicine And Molecular Imaging 2017, 44: 1538-1546. PMID: 28365789, DOI: 10.1007/s00259-017-3684-6.Peer-Reviewed Original ResearchConceptsMyocardial blood flowMicrosphere flow measurementsBlood flowStress myocardial blood flowSingle-scan protocolClinical applicationShort-axis viewMyocardial blood flow measurementsPET dataBlood flow changesIntroduction of adenosineHalf-life of 18FAdenosine infusionRadiotracer injectionAxis viewMyocardial segmentsHealthy pigsClinical translationPET acquisitionTwo-injectionPig modelIschemic areaPorcine modelHalf-lifeAdenosine
2016
Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR
Petibon Y, Guehl N, Reese T, Ebrahimi B, Normandin M, Shoup T, Alpert N, Fakhri G, Ouyang J. Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR. Physics In Medicine And Biology 2016, 62: 326-343. PMID: 27997375, PMCID: PMC5241952, DOI: 10.1088/1361-6560/aa5087.Peer-Reviewed Original ResearchConceptsSimultaneous PET-MRPET myocardial perfusion imagingMyocardial perfusion imagingPoint spread functionPoint-spread function correctionUngated dataMotion correctionPET-MRPartial volume effectsApparent wall thicknessMyocardial blood flowPartial volume effect correctionMR-based motion correctionMotion fieldPET-MR scannersPoint spread function modelPET dataPerfusion imagingImage qualityImpact of motionDynamic myocardial perfusion imagingAttenuation mapNon-rigid registrationAbsolute myocardial blood flowUngated images
2012
Single‐scan rest/stress imaging 18F‐labeled flow tracers
Alpert N, Fang Y, Fakhri G. Single‐scan rest/stress imaging 18F‐labeled flow tracers. Medical Physics 2012, 39: 6609-6620. PMID: 23127055, PMCID: PMC3482258, DOI: 10.1118/1.4754585.Peer-Reviewed Original Research
2010
WE‐D‐201B‐03: Recent Advances in PET Quantitation of Myocardial Blood Flow
Fakhri G. WE‐D‐201B‐03: Recent Advances in PET Quantitation of Myocardial Blood Flow. Medical Physics 2010, 37: 3433-3433. DOI: 10.1118/1.3469414.Peer-Reviewed Original Research
2009
Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET
Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, Fischman A, Coughlan M, Yasuda T, Di Carli M. Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET. Journal Of Nuclear Medicine 2009, 50: 1062-1071. PMID: 19525467, PMCID: PMC3133618, DOI: 10.2967/jnumed.104.007831.Peer-Reviewed Original ResearchConceptsCoronary flow reserveMyocardial blood flowQuantitation of myocardial blood flowTime-activity curvesInterobserver reliabilityBaseline myocardial blood flowBlood poolPET studiesAssessment of myocardial perfusionTissue time-activity curvesEstimation of myocardial blood flowMyocardial blood flow quantitationBland-Altman plotsBlood flow assessmentRight ventricular blood poolCompartment analysisMyocardial blood flow assessmentPeak stressVentricular blood poolReproducibility of myocardial blood flowDynamic restCardiac PETEstimation of coronary flow reserveIntraobserver variabilityMyocardial perfusionQuantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging
Curillova Z, Yaman B, Dorbala S, Kwong R, Sitek A, El Fakhri G, Anagnostopoulos C, Di Carli M. Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2009, 36: 1603-1610. PMID: 19387640, PMCID: PMC3117296, DOI: 10.1007/s00259-009-1121-1.Peer-Reviewed Original ResearchConceptsCoronary artery calcium scoreCoronary artery calciumCoronary vasodilator functionCoronary flow reserveCoronary artery diseaseHyperemic myocardial blood flowMyocardial blood flowVasodilator functionWeak inverse correlationCAC scoreCoronary artery calcium contentFlow reserveIncreasing CAC scorePer-vessel basisPer-patient basisInverse correlationBody mass indexCoronary calcium contentCoronary risk factorsCoronary vascular resistancePET/CT imagingConclusionIn patientsArtery calciumVascular resistanceMass index
2008
Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity
Anagnostopoulos C, Almonacid A, El Fakhri G, Curillova Z, Sitek A, Roughton M, Dorbala S, Popma J, Di Carli M. Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity. European Journal Of Nuclear Medicine And Molecular Imaging 2008, 35: 1593-1601. PMID: 18425513, PMCID: PMC3124702, DOI: 10.1007/s00259-008-0793-2.Peer-Reviewed Original ResearchConceptsPositron emission tomographyCoronary artery diseaseCoronary vasodilator reserveMyocardial blood flowPositron emission tomography imagingPercent diameter stenosisDiameter stenosisEmission tomographyAge-matchedStenosis severityHyperaemic myocardial blood flowRisk factorsStress myocardial blood flowVasodilator reserveFunctional assessment of coronary artery diseaseAssessment of coronary artery diseaseClinically useful tool