2014
4D numerical observer for lesion detection in respiratory‐gated PET
Lorsakul A, Li Q, Trott C, Hoog C, Petibon Y, Ouyang J, Laine A, Fakhri G. 4D numerical observer for lesion detection in respiratory‐gated PET. Medical Physics 2014, 41: 102504. PMID: 25281979, PMCID: PMC4281099, DOI: 10.1118/1.4895975.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationFluorodeoxyglucose F18HumansImage Interpretation, Computer-AssistedLung DiseasesModels, BiologicalMonte Carlo MethodMotionPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsRegression AnalysisRespiratory-Gated Imaging TechniquesSignal-To-Noise RatioConceptsRespiratory-gated positron emission tomographyMotion-corrected imagesDetection signal-to-noise ratioLesion detection taskNumerical observationsLesion detection performanceSignal-to-noise ratioPositron emission tomography sinogramsSpherical lesionsHotelling observerMotion correction methodPositron emission tomographyGeant4 ApplicationTomographic EmissionChannelized Hotelling observerAnthropomorphic phantomScanner geometryOSEM algorithmMonte Carlo simulationsPET framesImprove lesion detectionLesion detectionSignal-to-noise ratio measurementsActivity distributionConventional 3D approachEffect of time‐of‐flight and point spread function modeling on detectability of myocardial defects in PET
Schaefferkoetter J, Ouyang J, Rakvongthai Y, Nappi C, El Fakhri G. Effect of time‐of‐flight and point spread function modeling on detectability of myocardial defects in PET. Medical Physics 2014, 41: 062502. PMID: 24877836, PMCID: PMC4032408, DOI: 10.1118/1.4875725.Peer-Reviewed Original ResearchConceptsSignal-to-noise ratioDetection signal-to-noise ratioPoint spread functionObserver signal-to-noise ratioEffects of time-of-flightMyocardial defectsHuman observer performanceDefect detectionSlow convergenceTime-of-flight (TOFNon-PSFPostreconstruction smoothingFDG-PET dataTime-of-flightPSF reconstructionCombination of TOFNon-TOFIterationObserver performanceClinical practiceSpread functionReconstruction parametersReconstruction protocolsIterative methodDetection
2012
MRI-Based Nonrigid Motion Correction in Simultaneous PET/MRI
Chun Y, Reese T, Ouyang J, Guerin B, Catana C, Zhu X, Alpert N, Fakhri G. MRI-Based Nonrigid Motion Correction in Simultaneous PET/MRI. Journal Of Nuclear Medicine 2012, 53: 1284-1291. PMID: 22743250, PMCID: PMC4077320, DOI: 10.2967/jnumed.111.092353.Peer-Reviewed Original ResearchConceptsChannelized Hotelling observerMotion correctionDetection signal-to-noise ratioSignal-to-noise ratioMRI-based motion correctionRespiratory motion correctionMotion-corrected reconstructionOrdered-subsets expectation maximization algorithmNonrigid motion correctionChannelized Hotelling observer studyPET image qualityNonrigid image registration methodCoincidence dataDeformable phantomRespiratory gatingReduce radiation doseDynamic phantomImage registration methodReduced signal-to-noise ratioSimultaneous PET/MRICost of increased noiseHotelling observerPhantomAttenuation measurementsRabbit studies
2001
Optimization of Ga-67 Imaging for Detection and Estimation Tasks: Dependence of Imaging Performance on Choice of Energy Windows
Fakhri G, Moore S, Kijewski M. Optimization of Ga-67 Imaging for Detection and Estimation Tasks: Dependence of Imaging Performance on Choice of Energy Windows. 2001, 3: 1355-1357. DOI: 10.1109/nssmic.2001.1008588.Peer-Reviewed Original ResearchEnergy windowSignal-to-noise ratioMonte Carlo programDetection of spheresIdeal signal-to-noise ratioTorso phantomEstimation taskDetection signal-to-noise ratioPhantom acquisitionsSphere of radiusPhantom dataLower-energyPhotopeakImaging performancePhantomGa-67Detection metricsGa-67 imagingSphere sizeOptimal window widthWindow widthEnergyTaskQuantitative tasksOptimal window
2000
Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET
Moore S, Fakhri G, Badawi R, Van den Abbeele A, Zimmerman R. Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET. 2011 IEEE Nuclear Science Symposium Conference Record 2000, 3: 17/18-17/22 vol.3. DOI: 10.1109/nssmic.2000.949192.Peer-Reviewed Original ResearchField of viewNon-prewhiteningAxial field-of-viewMaximum ring differenceAnthropomorphic torso phantomClinically realistic phantomDetection of spheresNPW-SNRTorso phantomGe-68Head phantomDetection signal-to-noise ratioRing differenceRealistic phantomsPhantomBed positionF-18Signal-to-noise ratioActivity concentrationsTwo-dimensionalContrast levelsPET imagingCompare two-dimensionalModeFORE+FBP