2019
Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall.
Cebral J, Detmer F, Chung B, Choque-Velasquez J, Rezai B, Lehto H, Tulamo R, Hernesniemi J, Niemela M, Yu A, Williamson R, Aziz K, Shakur S, Amin-Hanjani S, Charbel F, Tobe Y, Robertson A, Frösen J. Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall. American Journal Of Neuroradiology 2019, 40: 510-516. PMID: 30733253, PMCID: PMC6420361, DOI: 10.3174/ajnr.a5970.Peer-Reviewed Original ResearchConceptsWall shear stressOscillatory shear indexGradient oscillatory numberOscillatory wall shear stressShear stressShear indexRelative residence timeWall shear stress gradientAverage wall shear stressFlow conditionsComputational fluid dynamics modelThin regionShear stress gradientLocal hemodynamicsFluid dynamics modelRecirculation zoneSwirling flowResidence timeStress gradientAneurysm hemodynamicsImpingement siteDynamic pressureAneurysm regionDynamic modelFlow stream
2018
Development and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics
Detmer F, Chung B, Mut F, Slawski M, Hamzei-Sichani F, Putman C, Jiménez C, Cebral J. Development and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics. International Journal Of Computer Assisted Radiology And Surgery 2018, 13: 1767-1779. PMID: 30094777, PMCID: PMC6328054, DOI: 10.1007/s11548-018-1837-0.Peer-Reviewed Original ResearchConceptsArea under the curveAneurysm locationMaximum oscillatory shear indexImage-based computational fluid dynamicsOscillatory shear indexComputational fluid dynamicsLow shear areaRisk of surgeryShear areaAdverse hemodynamic environmentShear indexFluid dynamicsHemodynamic environmentGeometric parametersPatient ageEndovascular treatmentIncreased rupture riskSubarachnoid hemorrhageAneurysm ruptureUnruptured aneurysmsPatient characteristicsTreatment strategiesInternal validityMale genderPatient gender