2024
What N Is N-ough for MRI-Based Animal Neuroimaging?
Grandjean J, Lake E, Pagani M, Mandino F. What N Is N-ough for MRI-Based Animal Neuroimaging? ENeuro 2024, 11: eneuro.0531-23.2024. PMID: 38499355, PMCID: PMC10950324, DOI: 10.1523/eneuro.0531-23.2024.Peer-Reviewed Original ResearchMultimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2022
A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth
Horien C, Greene A, Shen X, Fortes D, Brennan-Wydra E, Banarjee C, Foster R, Donthireddy V, Butler M, Powell K, Vernetti A, Mandino F, O'Connor D, Lake E, McPartland J, Volkmar F, Chun M, Chawarska K, Rosenberg M, Scheinost D, Constable R. A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth. Cerebral Cortex 2022, 33: 6320-6334. PMID: 36573438, PMCID: PMC10183743, DOI: 10.1093/cercor/bhac506.Peer-Reviewed Original ResearchConceptsAttention taskAttentional stateConnectome-based predictive modelingNeurodiverse conditionsSustained attention taskAttention network modelSample of youthNeurotypical participantsSustained attentionBrain correlatesNeurobiological correlatesAttention networkIndividual participantsSeparate samplesYouthParticipantsHead motionTaskCorrelatesAttentionAutismConfoundsNetwork modelGeneralizesHealthcare settings
2019
The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder
Lake EMR, Finn ES, Noble SM, Vanderwal T, Shen X, Rosenberg MD, Spann MN, Chun MM, Scheinost D, Constable RT. The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2019, 86: 315-326. PMID: 31010580, PMCID: PMC7311928, DOI: 10.1016/j.biopsych.2019.02.019.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderCerebral CortexConnectomeFemaleHumansLinear ModelsMagnetic Resonance ImagingMaleNerve NetSocial SkillsConceptsAttention-deficit/hyperactivity disorderAutism spectrum disorderSpectrum disorderFunctional connectivity profilesHyperactivity disorderBrain organizationAutism Brain Imaging Data ExchangeConnectome-based predictive modelingAutism Diagnostic Observation ScheduleAutism spectrum disorder traitsAutism spectrum disorder severitySocial Responsiveness Scale scoresADHD Rating Scale scoresFunctional magnetic resonance imagingBrain-behavior associationsSocial Responsiveness ScaleResting-state functional magnetic resonanceFunctional brain organizationFunctional magnetic resonanceADHD traitsNeurofunctional basisADHD symptomsSplit-half analysisResponsiveness ScaleSocial abilitiesTen simple rules for predictive modeling of individual differences in neuroimaging
Scheinost D, Noble S, Horien C, Greene AS, Lake EM, Salehi M, Gao S, Shen X, O’Connor D, Barron DS, Yip SW, Rosenberg MD, Constable RT. Ten simple rules for predictive modeling of individual differences in neuroimaging. NeuroImage 2019, 193: 35-45. PMID: 30831310, PMCID: PMC6521850, DOI: 10.1016/j.neuroimage.2019.02.057.Peer-Reviewed Original ResearchMeSH KeywordsBrainConnectomeHumansMachine LearningMagnetic Resonance ImagingModels, NeurologicalNeuroimagingConceptsBrain-behavior associations
2018
Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism
Bazzigaluppi P, Lake EM, Beckett TL, Koletar MM, Weisspapir I, Heinen S, Mester J, Lai A, Janik R, Dorr A, McLaurin J, Stanisz GJ, Carlen PL, Stefanovic B. Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism. Stroke 2018, 49: 2173-2181. PMID: 30354983, DOI: 10.1161/strokeaha.118.020586.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAcetoacetatesAnimalsAstrocytesBlood GlucoseBrainBrain IschemiaCell DeathCerebrovascular CirculationDisease Models, AnimalElectrophysiological PhenomenaEndothelin-1HemodynamicsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMicroinjectionsNeuronsRatsReactive Oxygen SpeciesSensorimotor CortexConceptsBody β-hydroxybutyrateFunctional recoveryMagnetic resonance imagingIschemic insultNeuronal deathResonance imagingFocal cortical strokeVehicle-administered animalsNeurological deficit scoresKetone body β-hydroxybutyrateNeuronal glucose uptakeContinuous arterial spinReduced oxidative stressPurpose Recent evidenceReactive oxygen species productionCortical microinjectionsCortical strokePostischemic hyperglycemiaDeficit scoresNeurovascular functionAcute phaseCerebrovascular reactivitySensorimotor cortexCerebral hemodynamicsEndothelin-1
2016
Modulation of the peri‐infarct neurogliovascular function by delayed COX‐1 inhibition
Lake EMR, Mester J, Thomason LA, Adams C, Bazzigaluppi P, Koletar M, Janik R, Carlen P, McLaurin J, Stanisz GJ, Stefanovic B. Modulation of the peri‐infarct neurogliovascular function by delayed COX‐1 inhibition. Journal Of Magnetic Resonance Imaging 2016, 46: 505-517. PMID: 28703413, DOI: 10.1002/jmri.25541.Peer-Reviewed Original ResearchConceptsNeuronal survivalMicroglia/macrophage recruitmentExerts multiple beneficial effectsChronic ischemic injuryAdult male ratsCOX-1 inhibitionMultiple beneficial effectsMost patientsAstrocytic activationEndothelial densityNeuronal lossChronic stageFocal ischemiaHemodynamic changesIschemic injuryAdult disabilityMacrophage recruitmentMale ratsPerfusion responseMore effective interventionsNeurogliovascular unitCOX-1Novel treatmentsPerfusionBeneficial effectsFunctional magnetic resonance imaging in chronic ischaemic stroke
Lake EM, Bazzigaluppi P, Stefanovic B. Functional magnetic resonance imaging in chronic ischaemic stroke. Philosophical Transactions Of The Royal Society B Biological Sciences 2016, 371: 20150353. PMID: 27574307, PMCID: PMC5003855, DOI: 10.1098/rstb.2015.0353.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingIschemic strokeInjury progressionLevel-dependent functional magnetic resonance imagingBlood oxygenation level-dependent functional magnetic resonance imagingChronic ischemic strokeBOLD functional magnetic resonance imagingBOLD signal contrastMagnetic resonance imagingFunctional magnetic resonanceBOLD fMRI measurementsVascular reactivityStroke progressionAdult disabilityChronic stageVascular functionPreclinical modelsStroke researchNeuronal activityNew treatmentsResonance imagingVivo markerClinical researchPreclinical researchBrain functionNeurovascular unit remodelling in the subacute stage of stroke recovery
Lake EMR, Bazzigaluppi P, Mester J, Thomason LAM, Janik R, Brown M, McLaurin J, Carlen PL, Corbett D, Stanisz GJ, Stefanovic B. Neurovascular unit remodelling in the subacute stage of stroke recovery. NeuroImage 2016, 146: 869-882. PMID: 27664828, DOI: 10.1016/j.neuroimage.2016.09.016.Peer-Reviewed Original ResearchConceptsPeri-lesional cortexVascular reactivityNeuronal lossSubacute stageEndothelin-1LFP activityLong-term functional outcomeLocal field potential responsesPeripheral somatosensory stimulationActivation of microgliaET-1 injectionFocal ischemic strokeFocal cerebral ischaemiaPeri-infarct zoneSensori-motor cortexSpontaneous neuronal activityAdult Sprague-DawleyField potential responsesExtended temporal windowDynamic functional changesIschemic strokeAstrocytic activationCerebral ischaemiaNeurovascular unitIschemic insult
2014
A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles
Oakden W, Kwiecien JM, O’Reilly M, Lake EM, Akens MK, Aubert I, Whyne C, Finkelstein J, Hynynen K, Stanisz GJ. A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles. Journal Of Neuroscience Methods 2014, 235: 92-100. PMID: 24970578, DOI: 10.1016/j.jneumeth.2014.06.018.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCervical spinal cord injuryMagnetic resonance imagingNon-surgical modelCord injurySpinal cordModel of SCIHuman spinal cord injuryT2-weighted magnetic resonance imagingFocused ultrasoundSpinal cord contusionCervical spinal cord damageSurgical incision siteSpinal cord damagePost-operative imagingCervical spinal cordDorsal spinal cordPost-operative careExtent of injuryDegree of injuryCord contusionAcute phaseCord damageVertebral systemSignal abnormalities