Hao Wu, MD, PhD
Associate Professor of PathologyCards
About
Research
Publications
2025
Histologic Glycogenic Acanthosis in the Distal Esophagus is Prevalent in Morbidly Obese Pediatric Patients Without Gastrointestinal Symptoms.
Krasinski C, Wu H. Histologic Glycogenic Acanthosis in the Distal Esophagus is Prevalent in Morbidly Obese Pediatric Patients Without Gastrointestinal Symptoms. International Journal Of Surgical Pathology 2025, 10668969251359942. PMID: 40686283, DOI: 10.1177/10668969251359942.Peer-Reviewed Original ResearchMetastatic Breast Cancer to a Dedifferentiated Solitary Fibrous Tumor Arising from a PTEN Hamartoma of Soft Tissue
Jiao J, Lindskog D, Laskin W, Wu H. Metastatic Breast Cancer to a Dedifferentiated Solitary Fibrous Tumor Arising from a PTEN Hamartoma of Soft Tissue. International Journal Of Surgical Pathology 2025, 33: 1856-1861. PMID: 40452397, DOI: 10.1177/10668969251343903.Peer-Reviewed Case Reports and Technical NotesDedifferentiated solitary fibrous tumorSolitary fibrous tumorPTEN hamartoma of soft tissueBreast cancerSoft tissueAssociated with other neoplasmsConventional solitary fibrous tumorMetastatic breast carcinomaGermline pathogenic variantsMetastatic breast cancerMetastatic ductal carcinomaPTEN hamartoma tumor syndromePlump spindle cellsDeep soft tissuesHamartoma tumor syndromePostzygotic mosaicismThin-walled vesselsPathogenic variantsPatternless patternFibrous tumorDuctal carcinomaBreast carcinomaGermline mutationsPediatric lesionsMyxoid background
2024
Use of Mitotic Activity and the Size of Any Dedifferentiated Component for Risk Assessment in MDM2-Amplified Liposarcoma.
Wu H, Sukhanova M, Tang H, Lu X, Zhong M, Deshpande H, Pollack S, Laskin W, Alexiev B. Use of Mitotic Activity and the Size of Any Dedifferentiated Component for Risk Assessment in MDM2-Amplified Liposarcoma. Archives Of Pathology & Laboratory Medicine 2024, 149: 422-430. PMID: 39164013, DOI: 10.5858/arpa.2024-0098-oa.Peer-Reviewed Original ResearchAtypical lipomatous tumor/well-differentiated liposarcomaMDM2-amplified liposarcomasDedifferentiated componentDedifferentiated liposarcomaAdverse eventsMitotic countLocal recurrence statusMDM2 copy numberAssociated with adverse eventsLog-rank testOverall tumor volumeUnivariate logistic regressionChromosome 12q13-15Statistically significant associationPercentage of cellsTumor dimensionTumor volumeTumor sizeMDM2 proto-oncogeneClinicopathological characteristicsPathology reportsGrade 3Recurrence statusUnivariate analysisMultivariate regression model
2023
Myxoinflammatory Fibroblastic Sarcoma
Wu H, Laskin W. Myxoinflammatory Fibroblastic Sarcoma. Surgical Pathology Clinics 2023, 17: 83-96. PMID: 38278610, DOI: 10.1016/j.path.2023.07.003.Chapters
2022
Clinical, Laboratory, and Histologic Correlates of Serum Antinuclear Antibody in Hispanic Pediatric Patients With Nonalcoholic Fatty Liver Disease
Wu H, Zhu L, Kinnear D, Triggs N, Quintanilla N, Himes R. Clinical, Laboratory, and Histologic Correlates of Serum Antinuclear Antibody in Hispanic Pediatric Patients With Nonalcoholic Fatty Liver Disease. American Journal Of Clinical Pathology 2022, 158: 221-227. PMID: 35311933, DOI: 10.1093/ajcp/aqac028.Peer-Reviewed Original ResearchConceptsANA-negative patientsNonalcoholic fatty liver diseasePediatric Hispanic patientsANA-positive patientsAntinuclear antibodiesFatty liver diseaseHistological diagnosisHispanic patientsSerum high-density lipoprotein (HDL) cholesterol levelsHistologic correlationHistological parametersHistological diagnosis of nonalcoholic fatty liver diseaseSignificance of antinuclear antibodiesLiver diseaseHigh-density lipoprotein (HDL) cholesterol levelsLow HDL cholesterol levelsInsulin resistanceCholesterol levelsAntinuclear antibody statusDiagnosis of nonalcoholic fatty liver diseasePositive ANA resultsPositive antinuclear antibodyHispanic pediatric patientsSerum antinuclear antibodiesHDL cholesterol levelsTesticular Juvenile Granulosa Cell Tumor - a Rare Entity that May Have Mildly Elevated Serum Alpha Fetal Protein in Infants
Zaheer S, Han L, Wu H. Testicular Juvenile Granulosa Cell Tumor - a Rare Entity that May Have Mildly Elevated Serum Alpha Fetal Protein in Infants. Pediatric And Developmental Pathology 2022, 25: 489-490. PMID: 35156876, DOI: 10.1177/10935266221075164.Peer-Reviewed Original Research
2021
Hemolysis in Early Infancy
Wu H, Tugal O, Perez-Atayde A. Hemolysis in Early Infancy. The American Journal Of Surgical Pathology 2021, 46: 801-808. PMID: 34856569, DOI: 10.1097/pas.0000000000001841.Peer-Reviewed Original ResearchConceptsGiant cell hepatitisNeonatal cholestasisRh incompatibilityHemolytic anemiaDifferential diagnosisDifferential diagnosis of neonatal cholestasisDiagnosis of neonatal cholestasisNeonatal giant cell hepatitisElevation of aspartate aminotransferaseAssociated with hemolysisAnti-D AntibodiesPerinatal infectionABO incompatibilityProphylactic useHepatobiliary abnormalitiesEarly infancyEarly diagnosisMetabolic disordersAlanine aminotransferaseAspartate aminotransferaseCholestasisAnemiaHepatitisHemolysisABOSULT1A1 and SULT1A2 Associated Extensive Prolapse-Type Inflammatory Polyposis in Crohn's Colitis.
Zhou T, Patel K, Harris R, Seghers V, Walsh S, Rodriguez R, Kellermayer R, Wu H. SULT1A1 and SULT1A2 Associated Extensive Prolapse-Type Inflammatory Polyposis in Crohn's Colitis. Annals Of Clinical & Laboratory Science 2021, 51: 868-874. PMID: 34921041.Peer-Reviewed Original ResearchConceptsMucosal prolapse syndromeMucosal prolapsePolygenic variationHomozygous single nucleotide polymorphismsCase of mucosal prolapse syndromeSolitary rectal ulcer syndromeProctitis cystica profundaAltered cell adhesionSingle nucleotide polymorphismsRectosigmoid colonColitis cystica profundaFibromuscular obliterationSplenic flexureEndoscopic appearanceCrohn's colitisDescending colonDiffuse polyposisNucleotide polymorphismsCrohn's diseaseLamina propriaMuscularis mucosaeCell adhesionPolyposisSyndromeInflammatory polyposis
2020
Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent
Wu H, Ye Q, Razzano D, Tugal O, Rosenblum J, Weigel T, Zhong M. Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent. Pediatric And Developmental Pathology 2020, 23: 472-475. PMID: 32924814, DOI: 10.1177/1093526620957219.Peer-Reviewed Original ResearchConceptsCribriform adenocarcinomaLung adenocarcinomaPrimary lung adenocarcinomaHealthy adolescent femalesSomatic CTNNB1 mutationsTissue of originCongenital malformationsCTNNB1 mutationsPediatric patientsMolecular alterationsHealthy adolescentsMolecular testingAdenocarcinomaSquamoid morulesAdolescent femalesSignaling pathwayPatientsMutationsMalignancyMalformationsTumorMorulesLungHistomorphology
2019
Granulomatous Appendicitis in the Pediatric Population
Wu H, Fuller M, Pogoriler J. Granulomatous Appendicitis in the Pediatric Population. Pediatric And Developmental Pathology 2019, 23: 215-221. PMID: 31619135, DOI: 10.1177/1093526619881545.Peer-Reviewed Original ResearchConceptsGranulomatous appendicitisInterval appendectomyCrohn's diseasePediatric populationClinically suspected acute appendicitisDiagnosis of inflammatory bowel diseaseLow diagnostic yieldAssociated with Crohn's diseaseInflammatory bowel diseaseAppendectomy specimensPerforated appendicitisRetrospective reviewAcute appendicitisDiagnostic yieldPediatric patientsBowel resectionClinical managementClinical significanceAppendectomyAppendicitisSpecial stainsPediatric institutionBowel diseaseInfectious organismsGranuloma
Clinical Care
Overview
Hao Wu, MD, PhD, is an anatomic pathologist who evaluates tissues, cells, and organs to help identify a variety of conditions. She provides specialized assessments in pediatric and placental pathology, as well as bone and soft tissue pathology, and performs autopsy evaluations to offer comprehensive insights for patient care.
Dr. Wu completed her medical training from Xi’an Medical University in China and earned her doctoral degree from Boston University. She pursued residency at Albany Medical Center and Boston Medical Center, followed by fellowship training in pediatric pathology at Boston Children’s Hospital and cytopathology at Boston Medical Center. She is an associate professor of pathology at Yale School of Medicine.
Clinical Specialties
Anatomic Pathology
Get In Touch
Contacts
Mailing Address
Yale School of Medicine
Department of Pathology, 310 Cedar St. BML B38, Yale School of Medicine
new haven, CT 06520-8023
United States