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Neuropathology Core

The Neuropathology Core is co-led by Drs. Anita Huttner MD, Director of Neuropathology, Pathology, and Caroline Zeiss PhD, Chief of Pathology, Comparative Medicine, and fulfills multiple important roles within the Yale Alzheimer's Disease Research Center (ADRC).

The Neuropathology Core (NP Core) provides an infrastructure for postmortem recovery and analysis of tissues from participants evaluated and followed in the Clinical Core. Detailed neuropathological assessments form the basis for the validation of clinical diagnoses, candidate antemortem biomarkers and imaging characteristics, and help uncover potential co-existing neurodegenerative or vascular disease processes. In addition, the NP Core serves as a biorepository for tissue samples and cell lines. Through systematic banking, cataloguing and distribution of well-annotated tissue samples, the NP Core forms a key component within the Yale ADRC. It enhances clinical, genetic, imaging, and biomarker research of ADRC investigators by enabling pathological correlations and tissue-based research throughout the broader research community.



  • Albert E. Kent Professor of Neuroscience and Professor of Psychology; Member, Kavli Institute of Neuroscience at Yale University

    Dr. Arnsten is an international expert on the molecular regulation of higher cortical circuits, and a member of the National Academy of Medicine. She received her B.A. in Neuroscience from Brown University in 1976 (where she created the Neuroscience major), and her Ph.D. in Neuroscience from UCSD in 1981. She did post-doctoral research with Dr. Susan Iversen at Cambridge University in the UK, and with Dr. Patricia Goldman-Rakic at Yale. Dr. Arnsten's research examines the neural basis of higher cognition. Her work has revealed that the newly evolved cortical circuits that underlie higher cognition are uniquely regulated at the molecular level, conferring vulnerability in mental illness and age-related cognitive disorders such as Alzheimer's Disease. Arnsten's research has led to new treatments for cognitive disorders in humans, including the successful translation of guanfacine (IntunivTM) for the treatment of ADHD and related prefrontal cortical disorders.
  • Assistant Professor of Pathology; Co-director, Yale Legacy Tissue Donation Program, Pathology

    I am a neuropathologist and researcher in neuroimmunology. My background is in electrophysiology and biomedical engineering of neural interface and neural information processing systems. My interests are in diseases of the central nervous system, including motor system diseases and cancer. I am working on advancing the techniques of computational pathology in order to better understand and diagnose diseases. My research involves the application of machine learning, image analysis, and statistics to histology and genomic data with the goal of better characterizing and classifying tumors. I am developing software to analyze histologic images taken from the kinds of slides produced in the routine clinical evaluation of tissue.  By using statistical and machine learning techniques, these algorithms look for patterns in cell placement and morphology that correspond to the tissue genetic profiles. I believe this simultaneous genotypic and phenotypic characterization of tumors will provide a deeper understanding of neurobiology, neuropathology, and caner immunology, and identify key elements of CNS microenvironments whose interactions advance our explanations and predictions of pathologic processes affecting the brain, retina, spinal cord, and peripheral nervous system.
  • Assistant Professor; Director of Autopsy Services, Pathology

    Dr. Sanchez received his undergraduate degree at Fairfield University, his medical degree at SUNY Stony Brook, and did his residency in anatomic and clinical pathology at Yale New Haven Hospital. He worked as a community pathologist at the Hospital of Central Connecticut before joining the Pathology Department at Yale School of Medicine where he is the Director of the Autopsy Service. In addition to surgical pathology his interests include autopsy pathology, microbiology, medical education, medical history, and quality management.