John Hwa MD, PhD

Associate Professor of Medicine (Cardiology); Director of Cardiovascular Pharmacogenetics

Departments & Organizations

Office of Student ResearchVascular Biology and Therapeutics ProgramInternal Medicine: Cardiovascular Medicine

Research Interests

Platelets; Diabetes Mellitus; Atherothrombosis; Prostacyclin; Thromboxane; NSAIDs more...


  • M.D., University of Sydney, 1986
  • Ph.D., Case Western Reserve Univ, 1996

Selected Publications

  • Tang W.H., Stitham J., Liu R., Gleim S., Spollett G., Martin K., Hwa J. Hyperglycemia promotes platelet apoptosis through a unique pathway involving aldose reductase, ROS, p53 and Bcl-xl. Circulation 2014 129(15):1598-609
  • Keramati A.R., Fathzadeh M., Singh R., Choi M., Faramarzi S., Mane S., Kasaei M., Sarajzadeh-Fard K., Hwa J., Kidd K.K., Babaee Bigi M.A., Malekzadeh R., Hosseinian A., Babaie M, Lifton R.P., Mani A.. Altered function of Dyrk1B is Associated with a Highly Penetrant Form of Obesity, Atherosclerosis and their Metabolic Risk Factors. N Engl J Med 2014 370(20):1909-19
  • Liu R, Yu J, Jin Y, Tang W, Qin L, Zhang X, Tellides G, Hwa J, Martin KA. TET2 is an mTORC1-dependent master regulator of vascular smooth muscle plasticity. Circulation 2013, 128(18):2047-57



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