David Pitt, MD

Assistant Professor of Neurology


Research Summary

Dr. Pitt's laboratory research focuses on neurodegenerative mechanisms in MS. In his projects he uses multiple approaches including inducible pluripotent stem cell-derived, patient-specific neuronal cultures, advanced histopathological analysis of brain tissue and ultra-highfield MR imaging of MS patients.


Selected Publications

  • Boster, A.L.; Nicholas, J.A; Topalli, I.; Kisanuki, Y.; Pei, W.; Morgan-Followell, B.; Kirsch, C.F.; Racke, M.K; Pitt, D.: Lessons Learned From Fatal Progressive Multifocal Leukoencephalopathy in a Natalizumab-Treated Multiple Sclerosis Patient. Archives of Neurology, accepted
  • Boster A., Bartoszek M.P., O’Connell C., Nicholas J., Morgan-Followell B., Pitt D. and Racke M. (2011): Efficacy, safety, and cost-effectiveness of glatiramer acetate in the treatment of relapsing-remitting multiple sclerosis (2011). Ther Adv Neurol Disord.. 4(5):319-32
  • Pitt D., Boster A., Pei W., Wohleb E., Jasne A. et al. (2010) Imaging cortical lesions in multiple sclerosis with ultra-highfield MRI. Arch. Neurol.67; 812-818
  • Pitt D., Gonzales E., Cross A.H. and Goldberg M.P. (2010) Dysmyelinated axons in shiverer mice are highly vulnerable to a-Amino-3-hydroxy-5-Methylisoxazole-4- Propionic Acid (AMPA) receptor-mediated toxicity. Brain Research 1309; pp 146- 54.
  • Pitt D., Nagelmeier I.E., Wilson H., Raine C.S. (2003): Glutamate uptake by oligodendrocytes in vitro: Implications for excitotoxicity in multiple sclerosis. Neurology 61; pp1113-200 PMID: 14581674
  • Werner P., Pitt D., C.S. Raine (2001): Glutamate excitotoxicity and axonal damage in lesions of multiple sclerosis. Ann Neurol 50(2), pp 169-80 PMID: 11506399
  • Pitt D., Werner P., Raine C.S. (2000): Glutamate excitotoxicity as a mechanism in multiple sclerosis? Nature Medicine 6; pp 67-70 PMID: 10613826

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