Center Publications

Publication Acknowledgment

To cite the Liver Center in your publications please use the following statement:

”This project was supported in part by the Yale Liver Center award NIH P30 DK034989 ________ core.”
(insert name of core(s) that you used-Morphology, Cellular Molecular, Clinical-Translational)

Liver Center Publications

2024

Electrocardiographic Abnormalities in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis.Dimala CA, Nso N, Wasserlauf J, Njei B. Curr Probl Cardiol. 2024 Apr 21; 2024 Apr 21. PMID: 38653446.
An explainable machine learning model for prediction of high-risk nonalcoholic steatohepatitis.Njei B, Osta E, Njei N, Al-Ajlouni YA, Lim JK. Sci Rep. 2024 Apr 13; 2024 Apr 13. PMID: 38615137.
Cardiovascular morbidity and mortality in lean vs. non-lean MASLD: A comprehensive meta-analysis.Nso N, Mergen D, Ikram M, Macrinici V, Hussain K, Lee K, Ugwendum D, Trimingham M, Balasubramanian S, Sam R, Njei B. Curr Probl Cardiol. 2024 Apr 8; 2024 Apr 8. PMID: 38599554.
Automated graded prognostic assessment for patients with hepatocellular carcinoma using machine learning.Gross M, Haider SP, Ze'evi T, Huber S, Arora S, Kucukkaya AS, Iseke S, Gebauer B, Fleckenstein F, Dewey M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Mar 27; 2024 Mar 27. PMID: 38536464.
Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study.Mezzacappa C, Rossi R, Jaffe A, Taddei TH, Strazzabosco M. Cancer Epidemiol Biomarkers Prev. 2024 Feb 6. PMID: 38059831.
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8(+) T-Cell Infiltration in Murine Hepatocellular Carcinoma.Shewarega A, Santana JG, Nam D, Berz A, Tefera J, Kahl V, Mishra SK, Coman D, Duncan J, Roberts SJ, Wetter A, Madoff DC, Chapiro J. Radiology. 2024 Feb. PMID: 38349244.
Modulation of canonical Wnt signaling regulates peribiliary mesenchymal identity during homeostasis and injury.Singh S, Budiman T, Redmond D, Gupta V. Hepatol Commun. 2024 Feb 1; 2024 Jan 22. PMID: 38251878.

2023

HCC is associated with diabetes and longitudinal blood glucose control in a national cohort with cirrhosis.Mezzacappa C, Mahmud N, Serper M, John BV, Taddei TH, Kaplan DE. Hepatol Commun. 2023 Dec 1; 2023 Dec 7. PMID: 38055642.
Heterogeneous murine peribiliary glands orchestrate compartmentalized epithelial renewal.Singh S, Lian Q, Budiman T, Taketo MM, Simons BD, Gupta V. Dev Cell. 2023 Dec 4; 2023 Oct 30. PMID: 37909044.
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.Song J, Lv H, Liu B, Hao M, Taylor HS, Zhang X, Li D, Huang Y. Mol Metab. 2023 Dec; 2023 Oct 28. PMID: 37898449.
LiverHccSeg: A publicly available multiphasic MRI dataset with liver and HCC tumor segmentations and inter-rater agreement analysis.Gross M, Arora S, Huber S, Kücükkaya AS, Onofrey JA. Data Brief. 2023 Dec; 2023 Oct 10. PMID: 37869619.
The Sympathetic Nervous System Promotes Hepatic Lymphangiogenesis, which Is Protective Against Liver Fibrosis.Tanaka M, Jeong J, Thomas C, Zhang X, Zhang P, Saruwatari J, Kondo R, McConnell MJ, Utsumi T, Iwakiri Y. Am J Pathol. 2023 Dec; 2023 Sep 4. PMID: 37673329.
HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis.Huang Y, Liangpunsakul S, Rudraiah S, Ma J, Keshipeddy SK, Wright D, Costa A, Burgess D, Zhang Y, Huda N, Wang L, Yang Z. Hepatol Commun. 2023 Nov 1; 2023 Nov 6. PMID: 37930124.
An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver.Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell MJ, Utsumi T, Iwakiri Y. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1; 2023 Aug 22. PMID: 37605828.
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation.Arumugam S, Li B, Boodapati SLT, Nathanson MH, Sun B, Ouyang X, Mehal WZ. Hepatology. 2023 Nov 1; 2023 Apr 5. PMID: 37013923.
Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease.Du Y, de Jong IEM, Gupta K, Waisbourd-Zinman O, Har-Zahav A, Soroka CJ, Boyer JL, Llewellyn J, Liu C, Naji A, Polacheck WJ, Wells RG. Biofabrication. 2023 Oct 20; 2023 Oct 20. PMID: 37820623.
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis.Mooring M, Yeung GA, Luukkonen P, Liu S, Akbar MW, Zhang GJ, Balogun O, Yu X, Mo R, Nejak-Bowen K, Poyurovsky MV, Booth CJ, Konnikova L, Shulman GI, Yimlamai D. Sci Transl Med. 2023 Sep 27; 2023 Sep 27. PMID: 37756381.
Protocol for enrichment, purification, and cytocentrifugation of mouse liver endothelial cells.Chowdhury S, Fried KD, Iwakiri Y, Brancale J, Vilarinho S. STAR Protoc. 2023 Sep 15; 2023 Jul 28. PMID: 37515764.
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia.Li X, Lozovatsky L, Tommasini SM, Fretz J, Finberg KE. Blood Adv. 2023 Sep 12. PMID: 37417950.
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.Qiu B, Lawan A, Xirouchaki CE, Yi JS, Robert M, Zhang L, Brown W, Fernández-Hernando C, Yang X, Tiganis T, Bennett AM. Nat Commun. 2023 Sep 5; 2023 Sep 5. PMID: 37669951.
Advancing diagnosis and management of liver disease in adults through exome sequencing.Zheng M, Hakim A, Konkwo C, Deaton AM, Ward LD, Silveira MG, Assis DN, Liapakis A, Jaffe A, Jiang ZG, Curry MP, Lai M, Cho MH, Dykas D, Bale A, Mistry PK, Vilarinho S. EBioMedicine. 2023 Sep; 2023 Aug 9. PMID: 37566928.
Acetate controls endothelial-to-mesenchymal transition.Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. Cell Metab. 2023 Jul 11; 2023 Jun 15. PMID: 37327791.
PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens.Damo M, Hornick NI, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza JL, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky WE, Leventhal JS, Krishnaswamy S, Joshi NS. Nature. 2023 Jul; 2023 Jun 21. PMID: 37344588.
Above the legal limit: Alcohol brings ER and mitochondria too close together.Guerra MT, Nathanson MH. Cell Calcium. 2023 Jul; 2023 May 22. PMID: 37235972.
Update in the Treatment of the Complications of Cirrhosis.Abraldes JG, Caraceni P, Ghabril M, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2023 Jul; 2023 Mar 25. PMID: 36972759.
Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK/STAT3 signaling.Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai SY, Boyer JL, Chai J. Hepatology. 2023 Jun 1; 2023 Jan 3. PMID: 36647589.
Adherence to Tumor Board Recommendations in the Treatment of Patients with Hepatocellular Carcinoma.Cao Y, Mezzacappa C, Jaffe A, Strazzabosco M, Taddei TH. J Multidiscip Healthc. 2023; 2023 May 31. PMID: 37283950.
A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.Li X, Jiang Q, Song G, Barkestani MN, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober JS, Jane-Wit D. Nat Commun. 2023 May 24; 2023 May 24. PMID: 37225719.
Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo.Akingbesote ND, Leitner BP, Jovin DG, Desrouleaux R, Owusu D, Zhu W, Li Z, Pollak MN, Perry RJ. Elife. 2023 May 23; 2023 May 23. PMID: 37219930.
Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation.Fiorotto R, Mariotti V, Taleb SA, Zehra SA, Nguyen M, Amenduni M, Strazzabosco M. Hepatol Commun. 2023 Apr 1; 2023 Mar 24. PMID: 36972396.
HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction.Subramanian K, Paul S, Libby A, Patterson J, Arterbery A, Knight J, Castaldi C, Wang G, Avitzur Y, Martinez M, Lobritto S, Deng Y, Geliang G, Kroemer A, Fishbein T, Mason A, Dominguez-Villar M, Mariappan M, Ekong UD. J Immunol. 2023 Mar 15. PMID: 36722941.
Experimental VX2 Rabbit Liver Tumor Model in Carbon Tetrachloride-Induced Cirrhosis of the Liver.Santana JG, Shewarega A, Nam D, Kahl V, Madoff DC, Zhang X, Chapiro J. J Vasc Interv Radiol. 2023 Mar; 2022 Dec 5. PMID: 36473611.
MR Imaging-Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver.Santana JG, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald LA, Boustani A, Walsh JJ, Kucukkaya AS, Malpani R, Madoff DC, Goldberg SN, Ahmed M, Joshi N, Coman D, Chapiro J. J Vasc Interv Radiol. 2023 Mar; 2022 Nov 21. PMID: 36423815.
Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type and sex specificity of gene expression with novel genetic risk for MERTK in female.Zhang L, He CH, Coffey S, Yin D, Hsu IU, Su C, Ye Y, Zhang C, Spurrier J, Nicholson L, Rothlin CV, Ghosh S, Gopal PP, Hafler DA, Zhao H, Strittmatter SM. medRxiv. 2023 Feb 23; 2023 Feb 23. PMID: 36865305.
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells.Sacirbegovic F, Günther M, Greco A, Zhao D, Wang X, Zhou M, Rosenberger S, Oberbarnscheidt MH, Held W, McNiff J, Jain D, Höfer T, Shlomchik WD. Immunity. 2023 Feb 14; 2023 Jan 30. PMID: 36720219.
Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis.Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Nat Commun. 2023 Feb 9; 2023 Feb 9. PMID: 36759512.
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis.Luukkonen PK, Sakuma I, Gaspar RC, Mooring M, Nasiri A, Kahn M, Zhang XM, Zhang D, Sammalkorpi H, Penttilä AK, Orho-Melander M, Arola J, Juuti A, Zhang X, Yimlamai D, Yki-Järvinen H, Petersen KF, Shulman GI. Proc Natl Acad Sci U S A. 2023 Jan 24; 2023 Jan 20. PMID: 36669104.
Bile Acid Induced Inflammation and the Role of β-Catenin.Boyer JL. Cell Mol Gastroenterol Hepatol. 2023; 2023 Sep 7. PMID: 37690462.
Clinicopathological significance of neutrophil-rich colorectal carcinoma.Rottmann BG, Patel N, Ahmed M, Deng Y, Ciarleglio M, Vyas M, Jain D, Zhang X. J Clin Pathol. 2023 Jan; 2021 Jul 26. PMID: 34312298.

2022

Locoregional Therapy in the Management of Intrahepatic Cholangiocarcinoma: Is There Sufficient Evidence to Guide Current Clinical Practice?Wang Y, Strazzabosco M, Madoff DC. Curr Oncol Rep. 2022 Dec; 2022 Oct 18. PMID: 36255606.
Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab-based model.Rabiee A, Deng Y, Ciarleglio M, Chan JL, Pons M, Genesca J, Garcia-Tsao G. Hepatol Commun. 2022 Dec; 2022 Oct 10. PMID: 36214066.
Holistic management of hepatocellular carcinoma: The hepatologist's comprehensive playbook.Jaffe A, Taddei TH, Giannini EG, Ilagan-Ying YC, Colombo M, Strazzabosco M. Liver Int. 2022 Dec; 2022 Oct 11. PMID: 36161463.
Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis.Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL, Assis DN, Ghonem NS. Inflammation. 2022 Dec; 2022 Jul 15. PMID: 35838934.
Diabetes medications and risk of HCC.Plaz Torres MC, Jaffe A, Perry R, Marabotto E, Strazzabosco M, Giannini EG. Hepatology. 2022 Dec; 2022 Mar 22. PMID: 35239194.
Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiota.Narasimhan S, Rajeevan N, Graham M, Wu MJ, DePonte K, Marion S, Masson O, O'Neal AJ, Pedra JHF, Sonenshine DE, Fikrig E. Microbiome. 2022 Oct 17; 2022 Oct 17. PMID: 36253842.
An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma.Madoff DC, Abi-Jaoudeh N, Braxton D, Goyal L, Jain D, Odisio BC, Salem R, Schattner M, Sheth R, Li D. Oncologist. 2022 Oct 1. PMID: 35925597.
Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation.Arumugam S, Qin Y, Liang Z, Han SN, Boodapati SLT, Li J, Lu Q, Flavell RA, Mehal WZ, Ouyang X. Cell Death Differ. 2022 Oct; 2022 Apr 27. PMID: 35477991.
Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.Ventura-Cots M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez-Pinto H, Costa A, Degré D, Fernandez-Carrillo C, Ganne-Carrie N, Garcia-Tsao G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez-Sanchez N, Miquel R, Moreno C, Mounajjed T, Odena G, Kim W, Sancho-Bru P, Warren Sands R, Szafranska J, Verset L, Schnabl B, Sempoux C, Shah V, Shawcross DL, Stauber RE, Straub BK, Verna E, Tiniakos D, Trépo E, Vargas V, Villanueva C, Woosley JT, Ziol M, Mueller S, Stärkel P, Bataller R. Gut. 2022 Sep; 2022 Jan 6. PMID: 34992134.
Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition.Xu L, Guo J, Moledina DG, Cantley LG. Nat Commun. 2022 Aug 19; 2022 Aug 19. PMID: 35986026.
Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy.Boddupalli CS, Nair S, Belinsky G, Gans J, Teeple E, Nguyen TH, Mehta S, Guo L, Kramer ML, Ruan J, Wang H, Davison M, Kumar D, Vidyadhara DJ, Zhang B, Klinger K, Mistry PK. Elife. 2022 Aug 16; 2022 Aug 16. PMID: 35972072.
Tissue-specific modifier alleles determine Mertk loss-of-function traits.Akalu YT, Mercau ME, Ansems M, Hughes LD, Nevin J, Alberto EJ, Liu XN, He LZ, Alvarado D, Keler T, Kong Y, Philbrick WM, Bosenberg M, Finnemann SC, Iavarone A, Lasorella A, Rothlin CV, Ghosh S. Elife. 2022 Aug 15; 2022 Aug 15. PMID: 35969037.
Early mechanical ventilation for grade IV hepatic encephalopathy is associated with increased mortality among patients with cirrhosis: an exploratory study.Saffo S, Garcia-Tsao G. Acute Crit Care. 2022 Aug; 2022 Aug 18. PMID: 35977889.
Interspecies commensal interactions have nonlinear impacts on host immunity.Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Cell Host Microbe. 2022 Jul 13; 2022 May 30. PMID: 35640610.
Within-host evolution of a gut pathobiont facilitates liver translocation.Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Kriegel MA, Palm NW. Nature. 2022 Jul; 2022 Jul 13. PMID: 35831502.
MR Imaging Biomarkers for the Prediction of Outcome after Radiofrequency Ablation of Hepatocellular Carcinoma: Qualitative and Quantitative Assessments of the Liver Imaging Reporting and Data System and Radiomic Features.Petukhova-Greenstein A, Zeevi T, Yang J, Chai N, DiDomenico P, Deng Y, Ciarleglio M, Haider SP, Onyiuke I, Malpani R, Lin M, Kucukkaya AS, Gottwald LA, Gebauer B, Revzin M, Onofrey J, Staib L, Gunabushanam G, Taddei T, Chapiro J. J Vasc Interv Radiol. 2022 Jul; 2022 Apr 20. PMID: 35460887.
Bile acids and their receptors: modulators and therapeutic targets in liver inflammation.Bertolini A, Fiorotto R, Strazzabosco M. Semin Immunopathol. 2022 Jul; 2022 Apr 12. PMID: 35415765.
Optimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI.Borde T, Nezami N, Laage Gaupp F, Savic LJ, Taddei T, Jaffe A, Strazzabosco M, Lin M, Duran R, Georgiades C, Hong K, Chapiro J. Radiology. 2022 Jul; 2022 Apr 12. PMID: 35412368.
Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model.Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. J Vasc Interv Radiol. 2022 Jul; 2022 Mar 26. PMID: 35346859.
Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease.Yao K, Tarabra E, Sia D, Morotti R, Fawaz R, Valentino P, Santoro N, Caprio S, Liu S, Yimlamai D. Hepatol Commun. 2022 Jul; 2022 Mar 21. PMID: 35312185.
Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma.Cadamuro M, Romanzi A, Guido M, Sarcognato S, Cillo U, Gringeri E, Zanus G, Strazzabosco M, Simioni P, Villa E, Fabris L. J Pers Med. 2022 Jun 30; 2022 Jun 30. PMID: 35887583.
Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1(-/-) mouse model of congenital hepatic fibrosis.Fabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M. FASEB J. 2022 Jun. PMID: 35593740.
Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration.Shin NS, Marlier A, Xu L, Doilicho N, Linberg D, Guo J, Cantley LG. J Am Soc Nephrol. 2022 Jun; 2022 May 16. PMID: 35577558.
Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro.Uthaya Kumar DB, Motakis E, Yurieva M, Kohar V, Martinek J, Wu TC, Khoury J, Grassmann J, Lu M, Palucka K, Kaminski N, Koff JL, Williams A. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1; 2022 Apr 19. PMID: 35438006.
Hepatic Adenomas in Patients 60 and Older Are Enriched for HNF1A Inactivation and Malignant Transformation.Yasir S, Chen ZE, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson MS. Am J Surg Pathol. 2022 Jun 1; 2022 Apr 6. PMID: 35383587.
Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance.Huang Y, Zhou JH, Zhang H, Canfran-Duque A, Singh AK, Perry RJ, Shulman GI, Fernandez-Hernando C, Min W. J Clin Invest. 2022 May 2. PMID: 35202005.
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis.Alrabadi LS, Dutton A, Rabiee A, Roberts SJ, Deng Y, Cusack L, Silveira MG, Ciarleglio M, Bucala R, Sinha R, Boyer JL, Assis DN. JHEP Rep. 2022 May; 2022 Feb 18. PMID: 35434588.
Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA-AH).Jiménez C, Ventura-Cots M, Sala M, Calafat M, Garcia-Retortillo M, Cirera I, Cañete N, Soriano G, Poca M, Simón-Talero M, Altamirano J, Lucey M, Garcia-Tsao G, Brown RS Jr, Schwabe RF, Verna EC, Schnabl B, Bosques-Padilla F, Mathurin P, Caballería J, Louvet A, Shawcross DL, Abraldes JG, Genescà J, Bataller R, Vargas V. Liver Int. 2022 May; 2022 Mar 7. PMID: 35220659.
Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease.Abraham C, Abreu MT, Turner JR. Gastroenterology. 2022 May; 2022 Feb 9. PMID: 35149024.
Primary Care Associated With Follow Up Viral Load Testing in Patients Cured of Hepatitis C Infection With Direct Acting Antivirals at a Multidisciplinary Addiction Treatment Program: Insights From a Real-World Setting.Haque LY, Butner JL, Shi JM, Henry S, Deng Y, Ciarleglio MM, Madden LM, Tetrault JM. J Addict Med. 2022 May-Jun 01. PMID: 34483278.
Immune landscape of human placental villi using single-cell analysis.Toothaker JM, Olaloye O, McCourt BT, McCourt CC, Silva TN, Case RM, Liu P, Yimlamai D, Tseng G, Konnikova L. Development. 2022 Apr 15; 2022 Feb 17. PMID: 35050308.
Ethnic and sex differences in hepatic lipid content and related cardiometabolic parameters in lean individuals.Petersen KF, Dufour S, Li F, Rothman DL, Shulman GI. JCI Insight. 2022 Apr 8; 2022 Apr 8. PMID: 35167495.
Citrullination of glucokinase is linked to autoimmune diabetes.Yang ML, Horstman S, Gee R, Guyer P, Lam TT, Kanyo J, Perdigoto AL, Speake C, Greenbaum CJ, Callebaut A, Overbergh L, Kibbey RG, Herold KC, James EA, Mamula MJ. Nat Commun. 2022 Apr 6; 2022 Apr 6. PMID: 35388005.
Let-7 underlies metformin-induced inhibition of hepatic glucose production.Xie D, Chen F, Zhang Y, Shi B, Song J, Chaudhari K, Yang SH, Zhang GJ, Sun X, Taylor HS, Li D, Huang Y. Proc Natl Acad Sci U S A. 2022 Apr 5; 2022 Mar 28. PMID: 35344434.
Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model.Doemel LA, Santana JG, Savic LJ, Gaupp FML, Borde T, Petukhova-Greenstein A, Kucukkaya AS, Schobert IT, Hamm CA, Gebauer B, Walsh JJ, Rexha I, Hyder F, Lin M, Madoff DC, Schlachter T, Chapiro J, Coman D. Eur Radiol. 2022 Apr; 2021 Oct 31. PMID: 34718844.
Cytoskeletal dynamics regulates stromal invasion behavior of distinct liver cancer subtypes.Nguyen RY, Xiao H, Gong X, Arroyo A, Cabral AT, Fischer TT, Flores KM, Zhang X, Robert ME, Ehrlich BE, Mak M. Commun Biol. 2022 Mar 3; 2022 Mar 3. PMID: 35241781.
Characterization of temporospatial distribution of renal tubular casts by nephron tracking after ischemia-reperfusion injury.Shin NS, Marlier A, Xu L, Lam T, Cantley LG, Guo JK. Am J Physiol Renal Physiol. 2022 Mar 1; 2022 Jan 31. PMID: 35100823.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X. J Biol Chem. 2022 Feb; 2022 Jan 5. PMID: 34998825.
The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.Morales-Arráez D, Ventura-Cots M, Altamirano J, Abraldes JG, Cruz-Lemini M, Thursz MR, Atkinson SR, Sarin SK, Kim W, Chavez-Araujo R, Higuera-de la Tijera MF, Singal AK, Shah VH, Kamath PS, Duarte-Rojo A, Charles EA, Vargas V, Jager M, Rautou PE, Rincon D, Zamarripa F, Restrepo-Gutiérrez JC, Torre A, Lucey MR, Arab JP, Mathurin P, Louvet A, García-Tsao G, González JA, Verna EC, Brown RS Jr, Argemi J, Fernández-Carrillo C, Clemente A, Alvarado-Tapias E, Forrest E, Allison M, Bataller R. Am J Gastroenterol. 2022 Feb 1. PMID: 34962498.
Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.Bhat N, Narayanan A, Fathzadeh M, Kahn M, Zhang D, Goedeke L, Neogi A, Cardone RL, Kibbey RG, Fernandez-Hernando C, Ginsberg HN, Jain D, Shulman GI, Mani A. J Clin Invest. 2022 Feb 1. PMID: 34855620.
Role of the IgG4-related cholangitis autoantigen annexin A11 in cholangiocyte protection.Herta T, Kersten R, Chang JC, Hubers L, Go S, Tolenaars D, Paulusma CC, Nathanson MH, Elferink RO, van de Graaf SFJ, Beuers U. J Hepatol. 2022 Feb; 2021 Oct 27. PMID: 34718050.
Oxidative stress and genotoxicity in 1,4-dioxane liver toxicity as evidenced in a mouse model of glutathione deficiency.Chen Y, Wang Y, Charkoftaki G, Orlicky DJ, Davidson E, Wan F, Ginsberg G, Thompson DC, Vasiliou V. Sci Total Environ. 2022 Feb 1; 2021 Sep 30. PMID: 34600989.
Correlation Between Clinical and Pathological Findings of Liver Injury in 27 Patients With Lethal COVID-19 Infections in Brazil.Santana MF, Guerra MT, Hundt MA, Ciarleglio MM, Pinto RAA, Dutra BG, Xavier MS, Lacerda MVG, Ferreira AJ, Wanderley DC, Borges do Nascimento IJ, Araújo RFA, Pinheiro SVB, Araújo SA, Leite MF, Ferreira LCL, Nathanson MH, Vieira Teixeira Vidigal P. Hepatol Commun. 2022 Feb; 2021 Sep 14. PMID: 34520633.
Trajectory of Serum Bilirubin Predicts Spontaneous Recovery in a Real-World Cohort of Patients With Alcoholic Hepatitis.Parker R, Cabezas J, Altamirano J, Arab JP, Ventura-Cots M, Sinha A, Dhanda A, Arrese M, McCune CA, Rowe IA, Schnabl B, Mathurin P, Shawcross D, Abraldes JG, Lucey MR, Garcia-Tsao G, Verna E, Brown RS Jr, Bosques-Padilla F, Vargas V, Louvet A, Holt AP, Bataller R. Clin Gastroenterol Hepatol. 2022 Feb; 2021 Jan 28. PMID: 33516950.
Invasive Fungal Infections Are Underdiagnosed in Hospitalized Patients With Decompensated Cirrhosis: An Autopsy Study.Saffo S, Jain D, Sanchez H, Garcia-Tsao G. Gastro Hep Adv. 2022; 2022 Jun 2. PMID: 36160304.
Inflammatory pathways and cholangiocarcinoma risk mechanisms and prevention.Cadamuro M, Strazzabosco M. Adv Cancer Res. 2022; 2022 Mar 10. PMID: 35961707.
Fermented Soy Drink (Q-CAN® PLUS) Induces Apoptosis and Reduces Viability of Cancer Cells.Ouyang X, Chen Y, Tejaswi BS, Arumugam S, Secor E, Weiss TR, Leapman M, Ali A. Nutr Cancer. 2022; 2022 May 23. PMID: 35603899.
Inositol 1,4,5-trisphosphate receptor type 3 is involved in resistance to apoptosis and maintenance of human hepatocellular carcinoma.Dos Santos ML, França A, Lima Filho ACM, Florentino RM, Diniz PH, Oliveira Lemos F, Gonçalves CAX, Coelho VL, Lima CX, Foureaux G, Nathanson MH, Vidigal PVT, Leite MF. Oncol Lett. 2022 Jan; 2021 Nov 25. PMID: 34966448.

2021

Improved performance and consistency of deep learning 3D liver segmentation with heterogeneous cancer stages in magnetic resonance imaging.Gross M, Spektor M, Jaffe A, Kucukkaya AS, Iseke S, Haider SP, Strazzabosco M, Chapiro J, Onofrey JA. PLoS One. 2021; 2021 Dec 1. PMID: 34852007.
Can We Rely on Changes in HVPG in Patients with Cirrhosis?Garcia-Tsao G. Hepatology. 2021 Dec; 2021 Oct 28. PMID: 34569630.
Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis.Gallucci GM, Trottier J, Hemme C, Assis DN, Boyer JL, Barbier O, Ghonem NS. Hepatol Commun. 2021 Dec; 2021 Aug 27. PMID: 34558841.
The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.Kuo WT, Zuo L, Odenwald MA, Madha S, Singh G, Gurniak CB, Abraham C, Turner JR. Gastroenterology. 2021 Dec; 2021 Aug 31. PMID: 34478742.
Pediatric Hepatocellular Adenomas: The Influence of Age and Syndrome on Subtype.Pacheco MC, Torbenson MS, Wu TT, Kakar S, Jain D, Yeh MM. Am J Surg Pathol. 2021 Dec 1. PMID: 34148984.
The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector.Tang X, Cao Y, Arora G, Hwang J, Sajid A, Brown CL, Mehta S, Marín-López A, Chuang YM, Wu MJ, Ma H, Pal U, Narasimhan S, Fikrig E. Elife. 2021 Nov 16; 2021 Nov 16. PMID: 34783654.
m(6)A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X. Cell Rep. 2021 Nov 9. PMID: 34758326.
Admission Urinary and Serum Metabolites Predict Renal Outcomes in Hospitalized Patients With Cirrhosis.Bajaj JS, Garcia-Tsao G, Reddy KR, O'Leary JG, Vargas HE, Lai JC, Kamath PS, Tandon P, Subramanian RM, Thuluvath P, Fagan A, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Wong F. Hepatology. 2021 Nov; 2021 Jul 8. PMID: 34002868.
A Historical Overview of Spontaneous Bacterial Peritonitis: From Rare to Resistant.Haque LY, Garcia-Tsao G. Clin Liver Dis (Hoboken). 2021 Oct; 2021 Oct 29. PMID: 34745584.
Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis.Jain D, Sreenivasan P, Inayat I, Deng Y, Ciarleglio MM, Garcia-Tsao G. Am J Clin Pathol. 2021 Oct 13. PMID: 33940622.
Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death.Chew M, Tang Z, Radcliffe C, Caruana D, Doilicho N, Ciarleglio MM, Deng Y, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2021 Oct; 2021 May 15. PMID: 34004326.
Increased Risk of ACLF and Inpatient Mortality in Hospitalized Patients with Cirrhosis and Hepatic Hydrothorax.O'Leary JG, Rajender Reddy K, Tandon P, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai JC, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Bajaj JS. Dig Dis Sci. 2021 Oct; 2020 Nov 13. PMID: 33185787.