David A. Calderwood PhD

Associate Professor of Pharmacology and of Cell Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Office of Student ResearchSignal TransductionVascular Biology and Therapeutics ProgramCell Biology | PharmacologyDiabetes Research CenterSignal Transduction

Research Interests

Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology more...


  • Ph.D., University of Manchester, UK, 1996

Selected Publications

  • Goult B. T, Bouaouina, M., Elliott, P.R., Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL. (2010) Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J. 29(6):1069-80.
  • Harburger DS, Bouaouina M, Calderwood DA. (2009) Kindlin-1 and -2 directly bind the C-terminal region of ß integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem. 284(17):11485-97. Epub 2009 Feb 23.
  • Chiswell B. P., Zhang R., Murphy J. W., Boggon T. J. and Calderwood D. A. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc. Natl. Acad. Sci. U.S.A. 105, 20677-20682



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