Welcome to the Calderwood Laboratory

The ability of cells to sense, adhere to and remodel the extracellular matrix that surrounds them is essential for multi-cellular life. The broad goal of research in the Calderwood lab is to understand the molecular basis of signaling to and from integrin adhesion receptors. We use a combination of structural, biochemical and cell biological approaches to investigate how integrin-associated intracellular proteins regulate integrin activation state, provide links from integrins to the actin cytoskeleton, control cell migration and morphogenesis, and assemble into signaling complexes.