Thomas Melia PhD

Assistant Professor of Cell Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Cell Biology: Membrane Traffic | Melia Lab

Research Interests

Macroautophagy; Autophagy more...


  • BS, Carnegie Mellon Univ, 1992
  • Ph.D., Baylor College of Medicine, 1999

Selected Publications

  • Choy, A., J. Dancourt, B. Mugo, T.J. O'Connor, R.R. Isberg, T.J. Melia*, and C.R. Roy. 2012. The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science, 338(6110): p. 1072-6.
  • Usha Nair, Anjali Jotwani, Jiefei Geng, Noor Gammoh, Diana Richerson, Wei-Lien Yen, Janice Griffith, Shanta Nag, Ke Wang, Tyler Moss, Fulvio Reggiori, Misuzu Baba, James A. McNew, Xuejun Jiang, Thomas J. Melia*, and Daniel J. Klionsky*. 2011. SNARE proteins are required for macroautophagy. Cell.
  • Jeong H., Then F., Melia, T., Mazzulli, J.R., Cui, L., Savas, J.N., Voisine, C., Tanese N., Hart A.C., Yamamoto, A. and Krainc, D.* 2009. Acetylation-Dependent Clearance of Soluble Mutant Huntingtin by Autophagy. Cell 137, 60-72.



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