Public Health Interests
Yale Combined Program in the Biological and Biomedical Sciences (BBS): Plant Molecular Biology
The future of food security will increasing depend on the ability to efficiently interpret large amounts of biological and environmental data. An essential objective will be to identify and characterize useful genetic diversity and use this information to rapidly respond to emerging biotic and abiotic threats using genomic selection, genome-editing and traditional breeding approaches. To implement these technologies, advances will be needed in high throughput genomics, phenomics and predictive statistical methods as it applies to populations. My lab develops genetic and genomic methods for plant population studies together with novel computation and predictive statistical methods to identify and characterize useful genetic diversity in plants. We work with international collaborators to develop strategies to generate extensive mapping populations and associated high-throughput genomic, computational and statistical methods to identify agronomic useful variants that will be the subject of genome-editing and selection for enhanced food security.
tasselseed1 is a lipoxygenase affecting jasmonic acid signaling in sex determination of maize
Acosta, I.F., Laparra, H., Romero, S.P., Schmelz, E., Hamberg, M., Mottinger, J.P., Moreno, M.A., and Dellaporta, S.L. (2009). tasselseed1 is a lipoxygenase affecting jasmonic acid signaling in sex determination of maize. Science (New York, NY 323, 262-265.
A hypervariable invertebrate allodeterminant
Nicotra, M.L., Powell, A.E., Rosengarten, R.D., Moreno, M., Grimwood, J., Lakkis, F.G., Dellaporta, S.L., and Buss, L.W. (2009). A hypervariable invertebrate allodeterminant. Curr Biol 19, 583-589.
Concatenated analysis sheds light on early metazoan evolution and fuels a modern "urmetazoon" hypothesis
Schierwater, B., Eitel, M., Jakob, W., Osigus, H.J., Hadrys, H., Dellaporta, S.L., Kolokotronis, S.O., and Desalle, R. (2009). Concatenated analysis sheds light on early metazoan evolution and fuels a modern "urmetazoon" hypothesis. PLoS biology 7, e20.
The Trichoplax genome and the nature of placozoans
Srivastava, M., Begovic, E., Chapman, J., Putnam, N.H., Hellsten, U., Kawashima, T., Kuo, A., Mitros, T., Salamov, A., Carpenter, M.L., et al. (2008). The Trichoplax genome and the nature of placozoans. Nature 454, 955-960.
Embryonic chimerism does not induce tolerance in an invertebrate model organism
Poudyal, M., et al. (2007). Embryonic chimerism does not induce tolerance in an invertebrate model organism. Proc. Natl. Acad. Sci. (USA) 104:4559-4564.
Axial patterning and diversification in the cnidaria predate the Hox system
Kamm, K., Schierwater, B., Jakob, W., Dellaporta, S.L., and Miller, D.J. (2006). Axial patterning and diversification in the cnidaria predate the Hox system. Curr. Biol. 16:920-926.